Social support in older individuals: The role of the BDNF Val66Met polymorphism

Warren D. Taylor, Stephan L Zuchner, Douglas R. McQuoid, David C. Steffens, Dan G. Blazer, K. Ranga R Krishnan

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Although often viewed as a purely environmental construct, perception of social support may be influenced by genetic factors. This study examined the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism andsocial support measures in older subjects. The sample consisted of 243 depressed and 115 non-depressed older subjects, age 60 years or older; 233 were Val66 allele homozygotes, while 125 were Met66 allele carriers. All subjects completed clinical assessments, including a self-report questionnaire assessing four social support domains, and provided blood for genotyping. Statistical models examined the relationship between scale scores of social support and BDNF Val66Met genotype, while controlling for presence or absence of major depressive disorder and other demographic factors significantly associated with social support. As social support measures were not normally distributed, log-transformed scores were examined. After controlling for diagnosis and education level, the Met66 allele was associated with lower levels of subjective social support (F1,357 = 5.33, P = 0.0216) and a trend for fewer social interactions (F1,357 = 3.66, P = 0.0567). Toour knowledge, this is the first report associating a measure of social support with a genetic polymorphism. This supports previous work that genetic factors may influence social support perception. Further work is needed to determine the generalizability of this finding to the broader population, as well as its significance for clinical outcomes.

Original languageEnglish
Pages (from-to)1205-1212
Number of pages8
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume147
Issue number7
DOIs
StatePublished - Oct 5 2008

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Brain-Derived Neurotrophic Factor
Social Support
Alleles
Social Perception
Major Depressive Disorder
Homozygote
Statistical Models
Genetic Polymorphisms
Interpersonal Relations
Self Report
Genotype
Demography
Education
Population

Keywords

  • Aging
  • Depression
  • Geriatrics
  • Polymorphism
  • Single nucleotide

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Social support in older individuals : The role of the BDNF Val66Met polymorphism. / Taylor, Warren D.; Zuchner, Stephan L; McQuoid, Douglas R.; Steffens, David C.; Blazer, Dan G.; Krishnan, K. Ranga R.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 147, No. 7, 05.10.2008, p. 1205-1212.

Research output: Contribution to journalArticle

Taylor, Warren D. ; Zuchner, Stephan L ; McQuoid, Douglas R. ; Steffens, David C. ; Blazer, Dan G. ; Krishnan, K. Ranga R. / Social support in older individuals : The role of the BDNF Val66Met polymorphism. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2008 ; Vol. 147, No. 7. pp. 1205-1212.
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