Social stress alters splenocyte phenotype and function

Ronit Avitsur, Jennifer L. Stark, Firdaus Dhabhar, John F. Sheridan

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Social stress of group-housed male mice induced a state of functional glucocorticoid (GC) resistance in splenocytes. The following studies examined the effects of paired-fighting (PF) stress on immune cell distribution and function in spleens of male mice. Following six daily PF stress sessions, splenic monocytes and neutrophils increased and lymphocytes decreased. PF also altered the distribution of CD62L and CD11b positive monocytes. Additionally, PF augmented proliferation and lowered the sensitivity of LPS-stimulated splenocytes to the antiproliferative effects of corticosterone, suggesting that PF induced a state of GC resistance in splenocytes. Together, these findings indicate that social stress altered phenotype and function of splenic immune cells. These findings may have implications for the healing of bite wounds that are often associated with social stress in rodents.

Original languageEnglish (US)
Pages (from-to)66-71
Number of pages6
JournalJournal of Neuroimmunology
Volume132
Issue number1-2
DOIs
StatePublished - Nov 1 2002
Externally publishedYes

Fingerprint

Monocytes
Phenotype
Bites and Stings
Corticosterone
Wound Healing
Rodentia
Neutrophils
Spleen
Lymphocytes
Glucocorticoid Receptor Deficiency

Keywords

  • CD11b
  • Corticosterone
  • Glucocorticoid resistance
  • LPS
  • Monocyte/macrophage
  • Social disruption

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Social stress alters splenocyte phenotype and function. / Avitsur, Ronit; Stark, Jennifer L.; Dhabhar, Firdaus; Sheridan, John F.

In: Journal of Neuroimmunology, Vol. 132, No. 1-2, 01.11.2002, p. 66-71.

Research output: Contribution to journalArticle

Avitsur, Ronit ; Stark, Jennifer L. ; Dhabhar, Firdaus ; Sheridan, John F. / Social stress alters splenocyte phenotype and function. In: Journal of Neuroimmunology. 2002 ; Vol. 132, No. 1-2. pp. 66-71.
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