Social disruption-induced glucocorticoid resistance: Kinetics and site specificity

Ronit Avitsur, Jennifer L. Stark, Firdaus Dhabhar, David A. Padgett, John F. Sheridan

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Social disruption (SDR) of male mice has been shown to induce a state of functional glucocorticoid (GC) resistance in splenocytes. The present study demonstrated that GC resistance developed following repeated, but not acute exposure to SDR. GC resistance was long-lasting and persisted for at least 10 days after stress. In contrast, SDR did not alter cytokine secretion from peritoneal mononuclear cells treated with corticosterone. These findings suggest that SDR-induced GC resistance may be restricted to specific sites such as the spleen.

Original languageEnglish (US)
Pages (from-to)54-61
Number of pages8
JournalJournal of Neuroimmunology
Volume124
Issue number1-2
DOIs
StatePublished - Mar 20 2002
Externally publishedYes

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Keywords

  • Corticosterone
  • Interleukin-6
  • Macrophages
  • Social stress

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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