SnapShot: Jak-STAT Signaling II

Alejandro V. Villarino, Massimo Gadina, John J. O'Shea, Yuka Kanno

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and transcription control. Discoveries in this field provided insights into primary immunodeficiencies, inherited autoimmune and autoinflammatory diseases, and hematologic and oncologic disorders, giving rise to a new class of drugs, JAK inhibitors (or Jakinibs).

Original languageEnglish (US)
Pages (from-to)1696-1696.e1
Issue number7
StatePublished - Jun 25 2020
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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