Smoothed Particle Hydrodynamics multiphase modelling of an experimental microfluidic device for conformal coating of pancreatic islets

Stefano Sibilla, Sauro Manenti, Tommaso Cazzato, Federica Colombo, Alice A. Tomei, Alberto Redaelli, Vita Manzoli, Filippo Consolo

Research output: Contribution to journalArticle

Abstract

The paper discusses a Smoothed Particle Hydrodynamics (SPH) model for the analysis of the multiphase flow occurring in an experimental microfluidic device for conformal coating of pancreatic islets with a biocompatible and permeable polymer. The proposed numerical model, based on a weakly-compressible SPH approach, accurately mimics the encapsulation process while assuring phase conservation, thus overcoming potential limitations of grid-based models. The proposed SPH model is a triphasic multi-phase model that allows one: (i) to reproduce the physics of islet conformal coating, including the effects of surface tension at the interface of the involved fluids and of the islet diameter; and (ii) to evaluate how modulation of process parameters influences the fluid dynamics within the microfluidic device and the resulting coating characteristics. This model can represent a valuable, time- and cost-effective tool for the definition of optimized encapsulation conditions through in silico screening of novel combinations of conformal coating parameters, including polymeric coating blends, size range of insulin-secreting cell clusters, utilized chemical reagents, device geometry and scale.

Original languageEnglish (US)
Pages (from-to)19-30
Number of pages12
JournalMedical Engineering and Physics
Volume77
DOIs
StatePublished - Mar 2020

Keywords

  • Biphasic fluid
  • Cell clusters
  • Encapsulation
  • Smoothed Particle Hydrodynamics
  • Surface tension

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering

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