@article{63d838d6d0ef4627b00ceed11d07077a,
title = "Smoothed Particle Hydrodynamics multiphase modelling of an experimental microfluidic device for conformal coating of pancreatic islets",
abstract = "The paper discusses a Smoothed Particle Hydrodynamics (SPH) model for the analysis of the multiphase flow occurring in an experimental microfluidic device for conformal coating of pancreatic islets with a biocompatible and permeable polymer. The proposed numerical model, based on a weakly-compressible SPH approach, accurately mimics the encapsulation process while assuring phase conservation, thus overcoming potential limitations of grid-based models. The proposed SPH model is a triphasic multi-phase model that allows one: (i) to reproduce the physics of islet conformal coating, including the effects of surface tension at the interface of the involved fluids and of the islet diameter; and (ii) to evaluate how modulation of process parameters influences the fluid dynamics within the microfluidic device and the resulting coating characteristics. This model can represent a valuable, time- and cost-effective tool for the definition of optimized encapsulation conditions through in silico screening of novel combinations of conformal coating parameters, including polymeric coating blends, size range of insulin-secreting cell clusters, utilized chemical reagents, device geometry and scale.",
keywords = "Biphasic fluid, Cell clusters, Encapsulation, Smoothed Particle Hydrodynamics, Surface tension",
author = "Stefano Sibilla and Sauro Manenti and Tommaso Cazzato and Federica Colombo and Tomei, {Alice A.} and Alberto Redaelli and Vita Manzoli and Filippo Consolo",
note = "Funding Information: This work was partially funded by Cariplo Foundation (grants 2011-2241 and 2015-1044). Funding for work performed in Dr. Tomei's lab was provided by philanthropic funds from the Diabetes Research Institute Foundation, grants from the Juvenile Diabetes Research Foundation (grant # 5-CDA-2016-171-S-B and JDRF 3-SRA-2017-347-M), the National Institute of Health (grant # DK109929). A.A.T. is a co-inventor of intellectual property used in the study and may gain royalties from future commercialization of the technology licensed to Converge Biotech Inc. A.A.T. and V.M. are stock option holders in Converge Biotech, licensee of some of the intellectual property used in this study. Not required. Funding Information: This work was partially funded by Cariplo Foundation (grants 2011-2241 and 2015-1044 ). Funding for work performed in Dr. Tomei's lab was provided by philanthropic funds from the Diabetes Research Institute Foundation , grants from the Juvenile Diabetes Research Foundation (grant # 5-CDA-2016-171-S-B and JDRF 3-SRA-2017-347-M ), the National Institute of Health (grant # DK109929 ). Publisher Copyright: {\textcopyright} 2020 IPEM",
year = "2020",
month = mar,
doi = "10.1016/j.medengphy.2020.01.004",
language = "English (US)",
volume = "77",
pages = "19--30",
journal = "Journal of Biomedical Engineering",
issn = "1350-4533",
publisher = "Elsevier BV",
}