Smoldering multiple myeloma: Present position and potential promises

Nishant Tageja, Elisabet E. Manasanch, Neha Korde, Mary Kwok, Sham Mailankody, Manisha Bhutani, Mark Roschewski, Ola Landgren

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Since smoldering multiple myeloma (SMM) was first described over three decades ago based on a case series of six patients, its definition and our understanding of the entity have evolved considerably. The risk of progression to symptomatic myeloma (MM) varies greatly among individuals diagnosed with myeloma precursor disease. Epidemiologic, molecular, flow cytometric and radiological techniques have demonstrated that this transformation to MM from precursor states is not sudden but rather a continuous overlapping series of events with evidence of end-organ damage that could manifest in the earliest stages of disease. Contemporary antimyeloma therapies can yield rapid, deep, and durable responses with manageable toxicities, and molecular-cell-based measures are now available to rule out minimal residual disease. With this information, clinical studies with correlative measures can now be developed to test the fundamental hypothesis that intervention in early myeloma may provide a measurable clinical benefit to patients by either delaying progression or eradicating plasma cell clones.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalEuropean Journal of Haematology
Volume92
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • Carfilzomib
  • Flow cytometry
  • Lenalidomide
  • Multiple myeloma
  • Plasma cell dyscrasia
  • Smoldering myeloma

ASJC Scopus subject areas

  • Hematology

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