Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease

Dana B. Hancock, Eden R Martin, Jeffrey M. Stajich, Rita Jewett, Mark A. Stacy, Burton L. Scott, Jeffery M Vance, William K Scott

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Objective: To assess associations between Parkinson disease (PD) and putatively protective factors - smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen). Design: Family-based case-control study. Setting: Academic medical center clinic. Participants: A total of 356 case subjects and 317 family controls who self-reported environmental exposures. Main Outcome Measures: Associations between PD and environmental measures (history, status, dosage, duration, and intensity) of smoking, coffee, caffeine, nonsteroidal anti-inflammatory drugs, and nonaspirin nonsteroidal anti-inflammatory drugs were examined using generalized estimating equations with an independent correlation matrix while controlling for age and sex. Results: Individuals withPDwere significantly less likely to report ever smoking (odds ratio = 0.56; 95% confidence interval, 0.41-0.78). Additional measures of smoking revealed significant inverse associations with PD (P<.05) and trends in odds ratios (P<.005). Increasing intensity of coffee drinking was inversely associated with PD (test for trendP = .05). Increasing dosage (trend P = .009) and intensity (trend P = .01) of total caffeine consumption were also inversely associated, with high dosage presenting a significant inverse association for PD (odds ratio = 0.58; 95% confidence interval, 0.34-0.99). There were no significant associations between nonsteroidal anti-inflammatory drugs and PD. Conclusions: Inverse associations of smoking and caffeine were corroborated using families with PD, thus emphasizing smoking and caffeine as important covariates to consider in genetic studies of PD.

Original languageEnglish
Pages (from-to)576-580
Number of pages5
JournalArchives of Neurology
Volume64
Issue number4
StatePublished - Apr 1 2007

Fingerprint

Caffeine
Parkinson Disease
Anti-Inflammatory Agents
Smoking
Pharmaceutical Preparations
Coffee
Odds Ratio
Confidence Intervals
Carbonated Beverages
Naproxen
Drugs
Parkinson's Disease
Ibuprofen
Environmental Exposure
Tea
Aspirin
Drinking
Case-Control Studies
History
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hancock, D. B., Martin, E. R., Stajich, J. M., Jewett, R., Stacy, M. A., Scott, B. L., ... Scott, W. K. (2007). Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease. Archives of Neurology, 64(4), 576-580.

Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease. / Hancock, Dana B.; Martin, Eden R; Stajich, Jeffrey M.; Jewett, Rita; Stacy, Mark A.; Scott, Burton L.; Vance, Jeffery M; Scott, William K.

In: Archives of Neurology, Vol. 64, No. 4, 01.04.2007, p. 576-580.

Research output: Contribution to journalArticle

Hancock DB, Martin ER, Stajich JM, Jewett R, Stacy MA, Scott BL et al. Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease. Archives of Neurology. 2007 Apr 1;64(4):576-580.
Hancock, Dana B. ; Martin, Eden R ; Stajich, Jeffrey M. ; Jewett, Rita ; Stacy, Mark A. ; Scott, Burton L. ; Vance, Jeffery M ; Scott, William K. / Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease. In: Archives of Neurology. 2007 ; Vol. 64, No. 4. pp. 576-580.
@article{584ab362e1a043c68c59967e1dcb6001,
title = "Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease",
abstract = "Objective: To assess associations between Parkinson disease (PD) and putatively protective factors - smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen). Design: Family-based case-control study. Setting: Academic medical center clinic. Participants: A total of 356 case subjects and 317 family controls who self-reported environmental exposures. Main Outcome Measures: Associations between PD and environmental measures (history, status, dosage, duration, and intensity) of smoking, coffee, caffeine, nonsteroidal anti-inflammatory drugs, and nonaspirin nonsteroidal anti-inflammatory drugs were examined using generalized estimating equations with an independent correlation matrix while controlling for age and sex. Results: Individuals withPDwere significantly less likely to report ever smoking (odds ratio = 0.56; 95{\%} confidence interval, 0.41-0.78). Additional measures of smoking revealed significant inverse associations with PD (P<.05) and trends in odds ratios (P<.005). Increasing intensity of coffee drinking was inversely associated with PD (test for trendP = .05). Increasing dosage (trend P = .009) and intensity (trend P = .01) of total caffeine consumption were also inversely associated, with high dosage presenting a significant inverse association for PD (odds ratio = 0.58; 95{\%} confidence interval, 0.34-0.99). There were no significant associations between nonsteroidal anti-inflammatory drugs and PD. Conclusions: Inverse associations of smoking and caffeine were corroborated using families with PD, thus emphasizing smoking and caffeine as important covariates to consider in genetic studies of PD.",
author = "Hancock, {Dana B.} and Martin, {Eden R} and Stajich, {Jeffrey M.} and Rita Jewett and Stacy, {Mark A.} and Scott, {Burton L.} and Vance, {Jeffery M} and Scott, {William K}",
year = "2007",
month = "4",
day = "1",
language = "English",
volume = "64",
pages = "576--580",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "4",

}

TY - JOUR

T1 - Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease

AU - Hancock, Dana B.

AU - Martin, Eden R

AU - Stajich, Jeffrey M.

AU - Jewett, Rita

AU - Stacy, Mark A.

AU - Scott, Burton L.

AU - Vance, Jeffery M

AU - Scott, William K

PY - 2007/4/1

Y1 - 2007/4/1

N2 - Objective: To assess associations between Parkinson disease (PD) and putatively protective factors - smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen). Design: Family-based case-control study. Setting: Academic medical center clinic. Participants: A total of 356 case subjects and 317 family controls who self-reported environmental exposures. Main Outcome Measures: Associations between PD and environmental measures (history, status, dosage, duration, and intensity) of smoking, coffee, caffeine, nonsteroidal anti-inflammatory drugs, and nonaspirin nonsteroidal anti-inflammatory drugs were examined using generalized estimating equations with an independent correlation matrix while controlling for age and sex. Results: Individuals withPDwere significantly less likely to report ever smoking (odds ratio = 0.56; 95% confidence interval, 0.41-0.78). Additional measures of smoking revealed significant inverse associations with PD (P<.05) and trends in odds ratios (P<.005). Increasing intensity of coffee drinking was inversely associated with PD (test for trendP = .05). Increasing dosage (trend P = .009) and intensity (trend P = .01) of total caffeine consumption were also inversely associated, with high dosage presenting a significant inverse association for PD (odds ratio = 0.58; 95% confidence interval, 0.34-0.99). There were no significant associations between nonsteroidal anti-inflammatory drugs and PD. Conclusions: Inverse associations of smoking and caffeine were corroborated using families with PD, thus emphasizing smoking and caffeine as important covariates to consider in genetic studies of PD.

AB - Objective: To assess associations between Parkinson disease (PD) and putatively protective factors - smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen). Design: Family-based case-control study. Setting: Academic medical center clinic. Participants: A total of 356 case subjects and 317 family controls who self-reported environmental exposures. Main Outcome Measures: Associations between PD and environmental measures (history, status, dosage, duration, and intensity) of smoking, coffee, caffeine, nonsteroidal anti-inflammatory drugs, and nonaspirin nonsteroidal anti-inflammatory drugs were examined using generalized estimating equations with an independent correlation matrix while controlling for age and sex. Results: Individuals withPDwere significantly less likely to report ever smoking (odds ratio = 0.56; 95% confidence interval, 0.41-0.78). Additional measures of smoking revealed significant inverse associations with PD (P<.05) and trends in odds ratios (P<.005). Increasing intensity of coffee drinking was inversely associated with PD (test for trendP = .05). Increasing dosage (trend P = .009) and intensity (trend P = .01) of total caffeine consumption were also inversely associated, with high dosage presenting a significant inverse association for PD (odds ratio = 0.58; 95% confidence interval, 0.34-0.99). There were no significant associations between nonsteroidal anti-inflammatory drugs and PD. Conclusions: Inverse associations of smoking and caffeine were corroborated using families with PD, thus emphasizing smoking and caffeine as important covariates to consider in genetic studies of PD.

UR - http://www.scopus.com/inward/record.url?scp=34247140154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247140154&partnerID=8YFLogxK

M3 - Article

VL - 64

SP - 576

EP - 580

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 4

ER -