Abstract
Objective: To assess associations between Parkinson disease (PD) and putatively protective factors - smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen). Design: Family-based case-control study. Setting: Academic medical center clinic. Participants: A total of 356 case subjects and 317 family controls who self-reported environmental exposures. Main Outcome Measures: Associations between PD and environmental measures (history, status, dosage, duration, and intensity) of smoking, coffee, caffeine, nonsteroidal anti-inflammatory drugs, and nonaspirin nonsteroidal anti-inflammatory drugs were examined using generalized estimating equations with an independent correlation matrix while controlling for age and sex. Results: Individuals withPDwere significantly less likely to report ever smoking (odds ratio = 0.56; 95% confidence interval, 0.41-0.78). Additional measures of smoking revealed significant inverse associations with PD (P<.05) and trends in odds ratios (P<.005). Increasing intensity of coffee drinking was inversely associated with PD (test for trendP = .05). Increasing dosage (trend P = .009) and intensity (trend P = .01) of total caffeine consumption were also inversely associated, with high dosage presenting a significant inverse association for PD (odds ratio = 0.58; 95% confidence interval, 0.34-0.99). There were no significant associations between nonsteroidal anti-inflammatory drugs and PD. Conclusions: Inverse associations of smoking and caffeine were corroborated using families with PD, thus emphasizing smoking and caffeine as important covariates to consider in genetic studies of PD.
| Original language | English |
|---|---|
| Pages (from-to) | 576-580 |
| Number of pages | 5 |
| Journal | Archives of Neurology |
| Volume | 64 |
| Issue number | 4 |
| State | Published - Apr 1 2007 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease. / Hancock, Dana B.; Martin, Eden R; Stajich, Jeffrey M.; Jewett, Rita; Stacy, Mark A.; Scott, Burton L.; Vance, Jeffery M; Scott, William K.
In: Archives of Neurology, Vol. 64, No. 4, 01.04.2007, p. 576-580.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease
AU - Hancock, Dana B.
AU - Martin, Eden R
AU - Stajich, Jeffrey M.
AU - Jewett, Rita
AU - Stacy, Mark A.
AU - Scott, Burton L.
AU - Vance, Jeffery M
AU - Scott, William K
PY - 2007/4/1
Y1 - 2007/4/1
N2 - Objective: To assess associations between Parkinson disease (PD) and putatively protective factors - smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen). Design: Family-based case-control study. Setting: Academic medical center clinic. Participants: A total of 356 case subjects and 317 family controls who self-reported environmental exposures. Main Outcome Measures: Associations between PD and environmental measures (history, status, dosage, duration, and intensity) of smoking, coffee, caffeine, nonsteroidal anti-inflammatory drugs, and nonaspirin nonsteroidal anti-inflammatory drugs were examined using generalized estimating equations with an independent correlation matrix while controlling for age and sex. Results: Individuals withPDwere significantly less likely to report ever smoking (odds ratio = 0.56; 95% confidence interval, 0.41-0.78). Additional measures of smoking revealed significant inverse associations with PD (P<.05) and trends in odds ratios (P<.005). Increasing intensity of coffee drinking was inversely associated with PD (test for trendP = .05). Increasing dosage (trend P = .009) and intensity (trend P = .01) of total caffeine consumption were also inversely associated, with high dosage presenting a significant inverse association for PD (odds ratio = 0.58; 95% confidence interval, 0.34-0.99). There were no significant associations between nonsteroidal anti-inflammatory drugs and PD. Conclusions: Inverse associations of smoking and caffeine were corroborated using families with PD, thus emphasizing smoking and caffeine as important covariates to consider in genetic studies of PD.
AB - Objective: To assess associations between Parkinson disease (PD) and putatively protective factors - smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen). Design: Family-based case-control study. Setting: Academic medical center clinic. Participants: A total of 356 case subjects and 317 family controls who self-reported environmental exposures. Main Outcome Measures: Associations between PD and environmental measures (history, status, dosage, duration, and intensity) of smoking, coffee, caffeine, nonsteroidal anti-inflammatory drugs, and nonaspirin nonsteroidal anti-inflammatory drugs were examined using generalized estimating equations with an independent correlation matrix while controlling for age and sex. Results: Individuals withPDwere significantly less likely to report ever smoking (odds ratio = 0.56; 95% confidence interval, 0.41-0.78). Additional measures of smoking revealed significant inverse associations with PD (P<.05) and trends in odds ratios (P<.005). Increasing intensity of coffee drinking was inversely associated with PD (test for trendP = .05). Increasing dosage (trend P = .009) and intensity (trend P = .01) of total caffeine consumption were also inversely associated, with high dosage presenting a significant inverse association for PD (odds ratio = 0.58; 95% confidence interval, 0.34-0.99). There were no significant associations between nonsteroidal anti-inflammatory drugs and PD. Conclusions: Inverse associations of smoking and caffeine were corroborated using families with PD, thus emphasizing smoking and caffeine as important covariates to consider in genetic studies of PD.
UR - http://www.scopus.com/inward/record.url?scp=34247140154&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247140154&partnerID=8YFLogxK
M3 - Article
C2 - 17420321
AN - SCOPUS:34247140154
VL - 64
SP - 576
EP - 580
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 4
ER -