Abstract
Context: Cigarette smoking is an established risk factor for urothelial carcinoma. Objective: To elucidate the association between pretreatment smoking status, cumulative exposure, and time since smoking cessation and the development of and outcomes for urothelial carcinoma of the bladder (UCB) in patients treated with transurethral resection of the bladder (TURBT) or radical cystectomy (RC). Evidence acquisition: A literature search was performed in September 2014 using the PubMed and Scopus databases limited to articles published in English since 1990. Eight contemporary studies on smoking and UBC development and 26 studies on smoking and UBC prognosis met the inclusion criteria. Evidence synthesis: Current cigarette smoking increases the risk of UCB incidence by two to fourfold, while smoking cessation attenuates this risk. Smoking status, exposure, and cessation have an evident impact on disease recurrence for patients who undergo TURBT, with weaker associations between smoking and other endpoints for TURBT and RC patients. Conclusion: Retrospective evidence suggests that smoking markedly increases UCB risk and may lead to unfavorable outcomes for patients who already have UCB; smoking cessation can attenuate these undesirable effects. Patient summary: Current evidence proves that cigarette smoking is an established risk factor for the development of urothelial carcinoma of the bladder (UCB). There is a growing body of evidence that smoking negatively affects outcomes for UCB patients treated with transurethral resection and/or radical cystectomy, although not uniformly. Long-term smoking cessation seems to mitigate the detrimental effects of smoking in non-muscle-invasive and muscle-invasive bladder cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 17-27 |
| Number of pages | 11 |
| Journal | European Urology Focus |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 1 2015 |
| Externally published | Yes |
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Keywords
- Intravesical therapy
- Muscle-invasive bladder cancer
- Non-muscle-invasive bladder cancer
- Progression
- Radical cystectomy
- Recurrence
- Smoking
- Survival
- Transurethral resection
- Urothelial carcinoma
ASJC Scopus subject areas
- Urology
Cite this
Smoking and Bladder Cancer : A Systematic Review of Risk and Outcomes. / Rink, Michael; Crivelli, Joseph J.; Shariat, Shahrokh F.; Chun, Felix K.; Messing, Edward M.; Soloway, Mark S.
In: European Urology Focus, Vol. 1, No. 1, 01.08.2015, p. 17-27.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Smoking and Bladder Cancer
T2 - A Systematic Review of Risk and Outcomes
AU - Rink, Michael
AU - Crivelli, Joseph J.
AU - Shariat, Shahrokh F.
AU - Chun, Felix K.
AU - Messing, Edward M.
AU - Soloway, Mark S.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Context: Cigarette smoking is an established risk factor for urothelial carcinoma. Objective: To elucidate the association between pretreatment smoking status, cumulative exposure, and time since smoking cessation and the development of and outcomes for urothelial carcinoma of the bladder (UCB) in patients treated with transurethral resection of the bladder (TURBT) or radical cystectomy (RC). Evidence acquisition: A literature search was performed in September 2014 using the PubMed and Scopus databases limited to articles published in English since 1990. Eight contemporary studies on smoking and UBC development and 26 studies on smoking and UBC prognosis met the inclusion criteria. Evidence synthesis: Current cigarette smoking increases the risk of UCB incidence by two to fourfold, while smoking cessation attenuates this risk. Smoking status, exposure, and cessation have an evident impact on disease recurrence for patients who undergo TURBT, with weaker associations between smoking and other endpoints for TURBT and RC patients. Conclusion: Retrospective evidence suggests that smoking markedly increases UCB risk and may lead to unfavorable outcomes for patients who already have UCB; smoking cessation can attenuate these undesirable effects. Patient summary: Current evidence proves that cigarette smoking is an established risk factor for the development of urothelial carcinoma of the bladder (UCB). There is a growing body of evidence that smoking negatively affects outcomes for UCB patients treated with transurethral resection and/or radical cystectomy, although not uniformly. Long-term smoking cessation seems to mitigate the detrimental effects of smoking in non-muscle-invasive and muscle-invasive bladder cancer.
AB - Context: Cigarette smoking is an established risk factor for urothelial carcinoma. Objective: To elucidate the association between pretreatment smoking status, cumulative exposure, and time since smoking cessation and the development of and outcomes for urothelial carcinoma of the bladder (UCB) in patients treated with transurethral resection of the bladder (TURBT) or radical cystectomy (RC). Evidence acquisition: A literature search was performed in September 2014 using the PubMed and Scopus databases limited to articles published in English since 1990. Eight contemporary studies on smoking and UBC development and 26 studies on smoking and UBC prognosis met the inclusion criteria. Evidence synthesis: Current cigarette smoking increases the risk of UCB incidence by two to fourfold, while smoking cessation attenuates this risk. Smoking status, exposure, and cessation have an evident impact on disease recurrence for patients who undergo TURBT, with weaker associations between smoking and other endpoints for TURBT and RC patients. Conclusion: Retrospective evidence suggests that smoking markedly increases UCB risk and may lead to unfavorable outcomes for patients who already have UCB; smoking cessation can attenuate these undesirable effects. Patient summary: Current evidence proves that cigarette smoking is an established risk factor for the development of urothelial carcinoma of the bladder (UCB). There is a growing body of evidence that smoking negatively affects outcomes for UCB patients treated with transurethral resection and/or radical cystectomy, although not uniformly. Long-term smoking cessation seems to mitigate the detrimental effects of smoking in non-muscle-invasive and muscle-invasive bladder cancer.
KW - Intravesical therapy
KW - Muscle-invasive bladder cancer
KW - Non-muscle-invasive bladder cancer
KW - Progression
KW - Radical cystectomy
KW - Recurrence
KW - Smoking
KW - Survival
KW - Transurethral resection
KW - Urothelial carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84940907013&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940907013&partnerID=8YFLogxK
U2 - 10.1016/j.euf.2014.11.001
DO - 10.1016/j.euf.2014.11.001
M3 - Article
AN - SCOPUS:84940907013
VL - 1
SP - 17
EP - 27
JO - European Urology Focus
JF - European Urology Focus
SN - 2405-4569
IS - 1
ER -