Small, dense low-density lipoprotein and C-reactive protein in obese subjects with and without other criteria for the metabolic syndrome

Gianluca Iacobellis, Maria Cristina Ribaudo, Alessandra Zappaterreno, Concetta Valeria Iannucci, Frida Leonetti

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Although obesity is an important cardiovascular risk factor, growing evidence shows that a substantial portion of obese subjects can be considered metabolically healthy but obese (MHO). However the extent to which obese subjects manifest small, dense low-density lipoprotein (LDL) particles without other characteristics of the metabolic syndrome (MS) remains unknown. Objective: The purpose of this study was to determine the difference between MHO (only meeting the obesity criteria) and obese subjects meeting all the criteria for the MS with regard to LDL size and high-sensitivity C-reactive protein (hs-CRP), as a biomarker of inflammation. Methods: Two hundred obese subjects (168 women, mean age 36.5 ± 5 years [range, 20-60]; mean body mass index [BMI; calculated as kg/m2] 39 ± 5 [range, 30-80.4]) were studied for LDL particles size and hs-CRP levels. Results: Of 200 enrolled obese subjects, 55 were defined MHO subjects meeting only obesity criteria. The other 145 met all five criteria and were defined as having MS. Although MHO and MS subjects had similar BMI, MHO subjects had a lower percentage of small LDL particles (8% vs 29%, P < 0.001), higher average LDL diameter (274 ± 5 vs 270 ± 7 Å, P < 0.001), and lower hs-CRP levels (P < 0.05) than MS patients. Conclusion: The major finding of this study is that MHO subjects compared to equally obese subjects meeting the criteria of the MS have statistically significant differences in size of LDL and concentration of hs-CRP. However, the absolute differences are very small and of uncertain clinical significance.

Original languageEnglish
Pages (from-to)599-604
Number of pages6
JournalJournal of Clinical Lipidology
Volume1
Issue number6
DOIs
StatePublished - Dec 1 2007
Externally publishedYes

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LDL Lipoproteins
C-Reactive Protein
Healthy Volunteers
Obesity
Particle Size
Body Mass Index
Biomarkers
Inflammation

Keywords

  • Atherosclerosis
  • LDL size
  • Metabolic syndrome
  • Metabolically healthy obese
  • Uncomplicated obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Nutrition and Dietetics

Cite this

Small, dense low-density lipoprotein and C-reactive protein in obese subjects with and without other criteria for the metabolic syndrome. / Iacobellis, Gianluca; Ribaudo, Maria Cristina; Zappaterreno, Alessandra; Iannucci, Concetta Valeria; Leonetti, Frida.

In: Journal of Clinical Lipidology, Vol. 1, No. 6, 01.12.2007, p. 599-604.

Research output: Contribution to journalArticle

Iacobellis, Gianluca ; Ribaudo, Maria Cristina ; Zappaterreno, Alessandra ; Iannucci, Concetta Valeria ; Leonetti, Frida. / Small, dense low-density lipoprotein and C-reactive protein in obese subjects with and without other criteria for the metabolic syndrome. In: Journal of Clinical Lipidology. 2007 ; Vol. 1, No. 6. pp. 599-604.
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N2 - Background: Although obesity is an important cardiovascular risk factor, growing evidence shows that a substantial portion of obese subjects can be considered metabolically healthy but obese (MHO). However the extent to which obese subjects manifest small, dense low-density lipoprotein (LDL) particles without other characteristics of the metabolic syndrome (MS) remains unknown. Objective: The purpose of this study was to determine the difference between MHO (only meeting the obesity criteria) and obese subjects meeting all the criteria for the MS with regard to LDL size and high-sensitivity C-reactive protein (hs-CRP), as a biomarker of inflammation. Methods: Two hundred obese subjects (168 women, mean age 36.5 ± 5 years [range, 20-60]; mean body mass index [BMI; calculated as kg/m2] 39 ± 5 [range, 30-80.4]) were studied for LDL particles size and hs-CRP levels. Results: Of 200 enrolled obese subjects, 55 were defined MHO subjects meeting only obesity criteria. The other 145 met all five criteria and were defined as having MS. Although MHO and MS subjects had similar BMI, MHO subjects had a lower percentage of small LDL particles (8% vs 29%, P < 0.001), higher average LDL diameter (274 ± 5 vs 270 ± 7 Å, P < 0.001), and lower hs-CRP levels (P < 0.05) than MS patients. Conclusion: The major finding of this study is that MHO subjects compared to equally obese subjects meeting the criteria of the MS have statistically significant differences in size of LDL and concentration of hs-CRP. However, the absolute differences are very small and of uncertain clinical significance.

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