Small Cell-like Change in Central Zone Histology—A New Observation Mimicking Cribriform Intraductal Prostatic Adenocarcinoma

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Abstract

A small cell-like change in prostate has been described in high-grade prostatic intraepithelial neoplasia (PIN), intraductal prostatic adenocarcinoma, and invasive prostate cancer. It occurs when these processes have a cribriform architecture. To date, small cell-like change has not been described in benign glands. Herein, I describe such a change in cribriform central zone histology from a radical prostatectomy with a spatially remote treatment naïve Grade Group 3 prostate cancer. The cancer did not have cribriform morphology or intraductal prostatic adenocarcinoma. The small cell-like change was positive for racemase in PIN-4 cocktail and no nuclei were highlighted by Ki-67. This is the first report of a small cell-like change in benign prostate tissue. Although rare, such finding in cribriform architecture of central zone histology can potentially be misinterpreted as a neoplastic process.

Original languageEnglish (US)
Pages (from-to)635-637
Number of pages3
JournalInternational Journal of Surgical Pathology
Volume29
Issue number6
DOIs
StatePublished - Sep 2021
Externally publishedYes

Keywords

  • central zone histology
  • cribriform
  • intraductal
  • mimicker
  • prostate
  • small cell-like

ASJC Scopus subject areas

  • Surgery
  • Anatomy
  • Pathology and Forensic Medicine

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