Small cell carcinoma of the prostate gland with inappropriate antidiuretic hormone secretion: Morphological, immunohistochemical and clinical expressions

L. Ghandur-Mnaymneh, S. Satterfield, Norman L Block

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Small cell carcinomas of the prostate gland are rare, and their histogenesis and clinical behavior remain poorly defined. We report a case with antidiuretic hormone secretion, which demonstrates direct transformation of the adenocarcinoma into the small cell component. The adenocarcinoma reacted positively for prostatic antigen, and negatively for carcinoembryonic antigen and neuron specific enolase, whereas the small cell component was negative for prostatic antigen, and positive for carcinoembryonic antigen and neuron specific enolase. At biopsy this was interpreted as denoting 2 separate tumors: one of prostatic and the other of nonprostatic origin. The clinical course was rapidly fatal but otherwise manifested the metastatic pattern of prostatic carcinoma. We caution that immunohistochemical reactions may be misleading if not interpreted in the context of other findings in the case. This case is labeled as a small cell carcinoma rather than a poorly differentiated adenocarcinoma of the ordinary type because the tumor exhibited morphological, immunohistochemical and biological features typical for that neoplasm.

Original languageEnglish
Pages (from-to)1263-1266
Number of pages4
JournalJournal of Urology
Volume135
Issue number6
StatePublished - Jan 1 1986

Fingerprint

Inappropriate ADH Syndrome
Small Cell Carcinoma
Prostate
Adenocarcinoma
Phosphopyruvate Hydratase
Carcinoembryonic Antigen
Cellular Structures
Antigens
Neoplasms
Vasopressins
Carcinoma
Biopsy

ASJC Scopus subject areas

  • Urology

Cite this

Small cell carcinoma of the prostate gland with inappropriate antidiuretic hormone secretion : Morphological, immunohistochemical and clinical expressions. / Ghandur-Mnaymneh, L.; Satterfield, S.; Block, Norman L.

In: Journal of Urology, Vol. 135, No. 6, 01.01.1986, p. 1263-1266.

Research output: Contribution to journalArticle

@article{c30eb31eaac246c68c7d874455dcd99e,
title = "Small cell carcinoma of the prostate gland with inappropriate antidiuretic hormone secretion: Morphological, immunohistochemical and clinical expressions",
abstract = "Small cell carcinomas of the prostate gland are rare, and their histogenesis and clinical behavior remain poorly defined. We report a case with antidiuretic hormone secretion, which demonstrates direct transformation of the adenocarcinoma into the small cell component. The adenocarcinoma reacted positively for prostatic antigen, and negatively for carcinoembryonic antigen and neuron specific enolase, whereas the small cell component was negative for prostatic antigen, and positive for carcinoembryonic antigen and neuron specific enolase. At biopsy this was interpreted as denoting 2 separate tumors: one of prostatic and the other of nonprostatic origin. The clinical course was rapidly fatal but otherwise manifested the metastatic pattern of prostatic carcinoma. We caution that immunohistochemical reactions may be misleading if not interpreted in the context of other findings in the case. This case is labeled as a small cell carcinoma rather than a poorly differentiated adenocarcinoma of the ordinary type because the tumor exhibited morphological, immunohistochemical and biological features typical for that neoplasm.",
author = "L. Ghandur-Mnaymneh and S. Satterfield and Block, {Norman L}",
year = "1986",
month = "1",
day = "1",
language = "English",
volume = "135",
pages = "1263--1266",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Small cell carcinoma of the prostate gland with inappropriate antidiuretic hormone secretion

T2 - Morphological, immunohistochemical and clinical expressions

AU - Ghandur-Mnaymneh, L.

AU - Satterfield, S.

AU - Block, Norman L

PY - 1986/1/1

Y1 - 1986/1/1

N2 - Small cell carcinomas of the prostate gland are rare, and their histogenesis and clinical behavior remain poorly defined. We report a case with antidiuretic hormone secretion, which demonstrates direct transformation of the adenocarcinoma into the small cell component. The adenocarcinoma reacted positively for prostatic antigen, and negatively for carcinoembryonic antigen and neuron specific enolase, whereas the small cell component was negative for prostatic antigen, and positive for carcinoembryonic antigen and neuron specific enolase. At biopsy this was interpreted as denoting 2 separate tumors: one of prostatic and the other of nonprostatic origin. The clinical course was rapidly fatal but otherwise manifested the metastatic pattern of prostatic carcinoma. We caution that immunohistochemical reactions may be misleading if not interpreted in the context of other findings in the case. This case is labeled as a small cell carcinoma rather than a poorly differentiated adenocarcinoma of the ordinary type because the tumor exhibited morphological, immunohistochemical and biological features typical for that neoplasm.

AB - Small cell carcinomas of the prostate gland are rare, and their histogenesis and clinical behavior remain poorly defined. We report a case with antidiuretic hormone secretion, which demonstrates direct transformation of the adenocarcinoma into the small cell component. The adenocarcinoma reacted positively for prostatic antigen, and negatively for carcinoembryonic antigen and neuron specific enolase, whereas the small cell component was negative for prostatic antigen, and positive for carcinoembryonic antigen and neuron specific enolase. At biopsy this was interpreted as denoting 2 separate tumors: one of prostatic and the other of nonprostatic origin. The clinical course was rapidly fatal but otherwise manifested the metastatic pattern of prostatic carcinoma. We caution that immunohistochemical reactions may be misleading if not interpreted in the context of other findings in the case. This case is labeled as a small cell carcinoma rather than a poorly differentiated adenocarcinoma of the ordinary type because the tumor exhibited morphological, immunohistochemical and biological features typical for that neoplasm.

UR - http://www.scopus.com/inward/record.url?scp=0022651823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022651823&partnerID=8YFLogxK

M3 - Article

C2 - 2423710

AN - SCOPUS:0022651823

VL - 135

SP - 1263

EP - 1266

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 6

ER -