Slow infusion of vinca alkaloids in the treatment of idiopathic thrombocytopenic purpura

Yeon Ahn, W. J. Harrington, R. Mylvaganam, L. M. Allen, L. M. Pall

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Vinca alkaloids are useful in the treatment of idiopathic thrombocytopenic purpura, a disorder in which macrophages remove platelets sensitized with antibody. Because vinca alkaloids avidly bind to platelets, drugs can be delivered selectively to macrophages. However, drugs given by bolus injection are cleared too rapidly to bind optimally to autologous platelets, and the use of allogeneic platelets loaded with drug in vitro is cumbersome, expensive, and dangerous. Therefore, slow infusions were devised to prolong the duration of enhanced plasma drug concentrations, thereby providing better conditions for in-vivo drug loading into autologous platelets. Twenty-four patients with refractory idiopathic thrombocytopenic purpura were given slow infusions; 17 had good to excellent responses. Eleven of eighteen patients who had been treated with bolus injections had better results when treated with slow infusions. Patients with improved responses had slower plasma clearance rates than did patients with poor responses. Slow infusion therapy had fewer side effects than bolus injection therapy. Slow infusions are the best method for long-term management.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalAnnals of Internal Medicine
Volume100
Issue number2
StatePublished - Apr 5 1984

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Vinca Alkaloids
Idiopathic Thrombocytopenic Purpura
Blood Platelets
Pharmaceutical Preparations
Injections
Macrophages
Therapeutics
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ahn, Y., Harrington, W. J., Mylvaganam, R., Allen, L. M., & Pall, L. M. (1984). Slow infusion of vinca alkaloids in the treatment of idiopathic thrombocytopenic purpura. Annals of Internal Medicine, 100(2), 192-196.

Slow infusion of vinca alkaloids in the treatment of idiopathic thrombocytopenic purpura. / Ahn, Yeon; Harrington, W. J.; Mylvaganam, R.; Allen, L. M.; Pall, L. M.

In: Annals of Internal Medicine, Vol. 100, No. 2, 05.04.1984, p. 192-196.

Research output: Contribution to journalArticle

Ahn, Y, Harrington, WJ, Mylvaganam, R, Allen, LM & Pall, LM 1984, 'Slow infusion of vinca alkaloids in the treatment of idiopathic thrombocytopenic purpura', Annals of Internal Medicine, vol. 100, no. 2, pp. 192-196.
Ahn Y, Harrington WJ, Mylvaganam R, Allen LM, Pall LM. Slow infusion of vinca alkaloids in the treatment of idiopathic thrombocytopenic purpura. Annals of Internal Medicine. 1984 Apr 5;100(2):192-196.
Ahn, Yeon ; Harrington, W. J. ; Mylvaganam, R. ; Allen, L. M. ; Pall, L. M. / Slow infusion of vinca alkaloids in the treatment of idiopathic thrombocytopenic purpura. In: Annals of Internal Medicine. 1984 ; Vol. 100, No. 2. pp. 192-196.
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