SLOW: A novel spectral editing method for whole-brain MRSI at ultra high magnetic field

Guodong Weng, Piotr Radojewski, Sulaiman Sheriff, Claus Kiefer, Philippe Schucht, Roland Wiest, Andrew A. Maudsley, Johannes Slotboom

Research output: Contribution to journalArticlepeer-review


Purpose: At ultra-high field (UHF), B1+-inhomogeneities and high specific absorption rate (SAR) of adiabatic slice-selective RF-pulses make spatial resolved spectral-editing extremely challenging with the conventional MEGA-approach. The purpose of the study was to develop a whole-brain resolved spectral-editing MRSI at UHF (UHF, B0 ≥ 7T) within clinical acceptable measurement-time and minimal chemical-shift-displacement-artifacts (CSDA) allowing for simultaneous GABA/Glx-, 2HG-, and PE-editing on a clinical approved 7T-scanner. Methods: Slice-selective adiabatic refocusing RF-pulses (2π-SSAP) dominate the SAR to the patient in (semi)LASER based MEGA-editing sequences, causing large CSDA and long measurement times to fulfill SAR requirements, even using SAR-minimized GOIA-pulses. Therefore, a novel type of spectral-editing, called SLOW-editing, using two different pairs of phase-compensated chemical-shift selective adiabatic refocusing-pulses (2π-CSAP) with different refocusing bandwidths were investigated to overcome these problems. Results: Compared to conventional echo-planar spectroscopic imaging (EPSI) and MEGA-editing, SLOW-editing shows robust refocusing and editing performance despite to B1+-inhomogeneity, and robustness to B0-inhomogeneities (0.2 ppm ≥ ΔB0 ≥ −0.2 ppm). The narrow bandwidth (∼0.6–0.8 kHz) CSAP reduces the SAR by 92%, RF peak power by 84%, in-excitation slab CSDA by 77%, and has no in-plane CSDA. Furthermore, the CSAP implicitly dephases water, lipid and all the other signals outside of range (≥ 4.6 ppm and ≤1.4 ppm), resulting in additional water and lipid suppression (factors ≥ 1000s) at zero SAR-cost, and no spectral aliasing artifacts. Conclusion: A new spectral-editing has been developed that is especially suitable for UHF, and was successfully applied for 2HG, GABA+, PE, and Glx-editing within 10 min clinical acceptable measurement time.

Original languageEnglish (US)
Pages (from-to)53-70
Number of pages18
JournalMagnetic Resonance in Medicine
Issue number1
StateAccepted/In press - 2022


  • 7T
  • H MRSI
  • J-difference editing
  • adiabatic pulse
  • chemical selective
  • whole-brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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