Sleep quality varies as a function of 5-HTTLPR genotype and stress

Beverly H. Brummett; Andrew D. Krystal; Allison Ashley-Koch; Cynthia M. Kuhn; Stephan Züchner; Ilene C. Siegler; John C. Barefoot; Edna L. Ballard; Lisa P. Gwyther; Redford B. Williams

doi:10.1097/PSY.0b013e31814b8de6

Sleep quality varies as a function of 5-HTTLPR genotype and stress

Beverly H. Brummett, Andrew D. Krystal, Allison Ashley-Koch, Cynthia M. Kuhn, Stephan Züchner, Ilene C. Siegler, John C. Barefoot, Edna L. Ballard, Lisa P. Gwyther, Redford B. Williams

Hussman Institute for Human Genomics

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. METHODS: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. RESULTS: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. CONCLUSIONS: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.

Original language	English (US)
Pages (from-to)	621-624
Number of pages	4
Journal	Psychosomatic medicine
Volume	69
Issue number	7
DOIs	https://doi.org/10.1097/PSY.0b013e31814b8de6
State	Published - Sep 2007

Keywords

5-HTTLPR
Gene-environment interaction
Serotonin transporter promoter gene polymorphism
Sleep quality
Stress

ASJC Scopus subject areas

Psychiatry and Mental health
Psychology(all)

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Sleep quality varies as a function of 5-HTTLPR genotype and stress. / Brummett, Beverly H.; Krystal, Andrew D.; Ashley-Koch, Allison; Kuhn, Cynthia M.; Züchner, Stephan; Siegler, Ilene C.; Barefoot, John C.; Ballard, Edna L.; Gwyther, Lisa P.; Williams, Redford B.

In: Psychosomatic medicine, Vol. 69, No. 7, 09.2007, p. 621-624.

Research output: Contribution to journal › Article › peer-review

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abstract = "OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. METHODS: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. RESULTS: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. CONCLUSIONS: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.",

keywords = "5-HTTLPR, Gene-environment interaction, Serotonin transporter promoter gene polymorphism, Sleep quality, Stress",

author = "Brummett, {Beverly H.} and Krystal, {Andrew D.} and Allison Ashley-Koch and Kuhn, {Cynthia M.} and Stephan Z{\"u}chner and Siegler, {Ilene C.} and Barefoot, {John C.} and Ballard, {Edna L.} and Gwyther, {Lisa P.} and Williams, {Redford B.}",

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AU - Brummett, Beverly H.

AU - Krystal, Andrew D.

AU - Ashley-Koch, Allison

AU - Kuhn, Cynthia M.

AU - Züchner, Stephan

AU - Siegler, Ilene C.

AU - Barefoot, John C.

AU - Ballard, Edna L.

AU - Gwyther, Lisa P.

AU - Williams, Redford B.

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