Sleep quality varies as a function of 5-HTTLPR genotype and stress

Beverly H. Brummett, Andrew D. Krystal, Allison Ashley-Koch, Cynthia M. Kuhn, Stephan L Zuchner, Ilene C. Siegler, John C. Barefoot, Edna L. Ballard, Lisa P. Gwyther, Redford B. Williams

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. METHODS: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. RESULTS: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. CONCLUSIONS: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.

Original languageEnglish
Pages (from-to)621-624
Number of pages4
JournalPsychosomatic Medicine
Volume69
Issue number7
DOIs
StatePublished - Sep 1 2007

Fingerprint

Sleep
Genotype
Serotonin Plasma Membrane Transport Proteins
Genes
Caregivers
Alleles
X-Linked Genes
Base Pairing
Dementia
Serotonin

Keywords

  • 5-HTTLPR
  • Gene-environment interaction
  • Serotonin transporter promoter gene polymorphism
  • Sleep quality
  • Stress

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Brummett, B. H., Krystal, A. D., Ashley-Koch, A., Kuhn, C. M., Zuchner, S. L., Siegler, I. C., ... Williams, R. B. (2007). Sleep quality varies as a function of 5-HTTLPR genotype and stress. Psychosomatic Medicine, 69(7), 621-624. https://doi.org/10.1097/PSY.0b013e31814b8de6

Sleep quality varies as a function of 5-HTTLPR genotype and stress. / Brummett, Beverly H.; Krystal, Andrew D.; Ashley-Koch, Allison; Kuhn, Cynthia M.; Zuchner, Stephan L; Siegler, Ilene C.; Barefoot, John C.; Ballard, Edna L.; Gwyther, Lisa P.; Williams, Redford B.

In: Psychosomatic Medicine, Vol. 69, No. 7, 01.09.2007, p. 621-624.

Research output: Contribution to journalArticle

Brummett, BH, Krystal, AD, Ashley-Koch, A, Kuhn, CM, Zuchner, SL, Siegler, IC, Barefoot, JC, Ballard, EL, Gwyther, LP & Williams, RB 2007, 'Sleep quality varies as a function of 5-HTTLPR genotype and stress', Psychosomatic Medicine, vol. 69, no. 7, pp. 621-624. https://doi.org/10.1097/PSY.0b013e31814b8de6
Brummett BH, Krystal AD, Ashley-Koch A, Kuhn CM, Zuchner SL, Siegler IC et al. Sleep quality varies as a function of 5-HTTLPR genotype and stress. Psychosomatic Medicine. 2007 Sep 1;69(7):621-624. https://doi.org/10.1097/PSY.0b013e31814b8de6
Brummett, Beverly H. ; Krystal, Andrew D. ; Ashley-Koch, Allison ; Kuhn, Cynthia M. ; Zuchner, Stephan L ; Siegler, Ilene C. ; Barefoot, John C. ; Ballard, Edna L. ; Gwyther, Lisa P. ; Williams, Redford B. / Sleep quality varies as a function of 5-HTTLPR genotype and stress. In: Psychosomatic Medicine. 2007 ; Vol. 69, No. 7. pp. 621-624.
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