Sleep quality varies as a function of 5-HTTLPR genotype and stress

Beverly H. Brummett; Andrew D. Krystal; Allison Ashley-Koch; Cynthia M. Kuhn; Stephan Züchner; Ilene C. Siegler; John C. Barefoot; Edna L. Ballard; Lisa P. Gwyther; Redford B. Williams

doi:10.1097/PSY.0b013e31814b8de6

Sleep quality varies as a function of 5-HTTLPR genotype and stress

Beverly H. Brummett, Andrew D. Krystal, Allison Ashley-Koch, Cynthia M. Kuhn, Stephan Züchner, Ilene C. Siegler, John C. Barefoot, Edna L. Ballard, Lisa P. Gwyther, Redford B. Williams

Hussman Institute for Human Genomics

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. METHODS: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. RESULTS: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. CONCLUSIONS: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.

Original language	English (US)
Pages (from-to)	621-624
Number of pages	4
Journal	Psychosomatic medicine
Volume	69
Issue number	7
DOIs	https://doi.org/10.1097/PSY.0b013e31814b8de6
State	Published - Sep 2007

Keywords

5-HTTLPR
Gene-environment interaction
Serotonin transporter promoter gene polymorphism
Sleep quality
Stress

ASJC Scopus subject areas

Psychiatry and Mental health
Psychology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/PSY.0b013e31814b8de6

Cite this

Sleep quality varies as a function of 5-HTTLPR genotype and stress. / Brummett, Beverly H.; Krystal, Andrew D.; Ashley-Koch, Allison; Kuhn, Cynthia M.; Züchner, Stephan; Siegler, Ilene C.; Barefoot, John C.; Ballard, Edna L.; Gwyther, Lisa P.; Williams, Redford B.

In: Psychosomatic medicine, Vol. 69, No. 7, 09.2007, p. 621-624.

Research output: Contribution to journal › Article › peer-review

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abstract = "OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. METHODS: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. RESULTS: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. CONCLUSIONS: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.",

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AU - Ashley-Koch, Allison

AU - Kuhn, Cynthia M.

AU - Züchner, Stephan

AU - Siegler, Ilene C.

AU - Barefoot, John C.

AU - Ballard, Edna L.

AU - Gwyther, Lisa P.

AU - Williams, Redford B.

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N2 - OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. METHODS: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. RESULTS: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. CONCLUSIONS: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.

AB - OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. METHODS: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. RESULTS: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. CONCLUSIONS: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.

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Sleep quality varies as a function of 5-HTTLPR genotype and stress

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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