Abstract
OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. METHODS: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. RESULTS: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. CONCLUSIONS: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.
| Original language | English |
|---|---|
| Pages (from-to) | 621-624 |
| Number of pages | 4 |
| Journal | Psychosomatic Medicine |
| Volume | 69 |
| Issue number | 7 |
| DOIs | |
| State | Published - Sep 1 2007 |
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Keywords
- 5-HTTLPR
- Gene-environment interaction
- Serotonin transporter promoter gene polymorphism
- Sleep quality
- Stress
ASJC Scopus subject areas
- Psychiatry and Mental health
- Psychology(all)
Cite this
Sleep quality varies as a function of 5-HTTLPR genotype and stress. / Brummett, Beverly H.; Krystal, Andrew D.; Ashley-Koch, Allison; Kuhn, Cynthia M.; Zuchner, Stephan L; Siegler, Ilene C.; Barefoot, John C.; Ballard, Edna L.; Gwyther, Lisa P.; Williams, Redford B.
In: Psychosomatic Medicine, Vol. 69, No. 7, 01.09.2007, p. 621-624.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sleep quality varies as a function of 5-HTTLPR genotype and stress
AU - Brummett, Beverly H.
AU - Krystal, Andrew D.
AU - Ashley-Koch, Allison
AU - Kuhn, Cynthia M.
AU - Zuchner, Stephan L
AU - Siegler, Ilene C.
AU - Barefoot, John C.
AU - Ballard, Edna L.
AU - Gwyther, Lisa P.
AU - Williams, Redford B.
PY - 2007/9/1
Y1 - 2007/9/1
N2 - OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. METHODS: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. RESULTS: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. CONCLUSIONS: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.
AB - OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. METHODS: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. RESULTS: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. CONCLUSIONS: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.
KW - 5-HTTLPR
KW - Gene-environment interaction
KW - Serotonin transporter promoter gene polymorphism
KW - Sleep quality
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=34648826618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34648826618&partnerID=8YFLogxK
U2 - 10.1097/PSY.0b013e31814b8de6
DO - 10.1097/PSY.0b013e31814b8de6
M3 - Article
C2 - 17766685
AN - SCOPUS:34648826618
VL - 69
SP - 621
EP - 624
JO - Psychosomatic Medicine
JF - Psychosomatic Medicine
SN - 0033-3174
IS - 7
ER -