Sleep quality mediates the relationship between frailty and cognitive dysfunction in non-demented middle aged to older adults

Sonya Kaur, Nikhil Banerjee, Michelle Miranda, Mitchell Slugh, Ni Sun-Suslow, Katalina F. McInerney, Xiaoyan Sun, Alberto R. Ramos, Tatjana Rundek, Ralph L. Sacco, Bonnie E. Levin

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objectives: Frailty is associated with cognitive decline in older adults. However, the mechanisms explaining this relationship are poorly understood. We hypothesized that sleep quality may mediate the relationship between frailty and cognition.Participants: 154 participants aged between 50-90 years (mean = 69.1 years, SD = 9.2 years) from the McKnight Brain Registry were included.Measurements: Participants underwent a full neuropsychological evaluation, frailty and subjective sleep quality assessments. Direct relationships between frailty and cognitive function were assessed using linear regression models. Statistical mediation of these relationships by sleep quality was assessed using nonparametric bootstrapping procedures.Results: Frailty severity predicted weaker executive function (B = -2.77, β = -0.30, 95% CI = -4.05 - -1.29) and processing speed (B = -1.57, β = -0.17, 95% CI = -3.10 - -0.16). Poor sleep quality predicted poorer executive function (B = -0.47, β = -0.21, 95% CI = -0.79 - -0.08), processing speed (B = -0.64, β = -0.28, 95% CI = -0.98 - -0.31), learning (B = -0.42, β = -0.19, 95% CI = -0.76 - -0.05) and delayed recall (B = -0.41, β = -0.16, 95% CI = -0.80 - -0.31). Poor sleep quality mediated the relationships between frailty severity and executive function (B = -0.66, β = -0.07, 95% CI = -1.48 - -0.39), learning (B = -0.85, β = -0.07, 95% CI = -1.85 - -0.12), delayed recall (B = -0.47, β = -0.08, 95% CI = -2.12 - -0.39) and processing speed (B = -0.90, β = -0.09, 95% CI = -1.85 - -0.20).Conclusions: Relationships between frailty severity and several cognitive outcomes were significantly mediated by poor sleep quality. Interventions to improve sleep quality may be promising avenues to prevent cognitive decline in frail older adults.

Original languageEnglish (US)
Pages (from-to)779-788
Number of pages10
JournalInternational Psychogeriatrics
Volume31
Issue number6
DOIs
StatePublished - Jun 1 2019

Keywords

  • Frailty
  • cognitive function
  • older adults
  • sleep quality

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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