Sleep duration is associated with survival in advanced cancer patients

Kevin P. Collins, David A. Geller, Michael H Antoni, Drew Michael Donnell, Allan Tsung, James W. Marsh, Lora Burke, Frank Penedo, Lauren Terhorst, Thomas W. Kamarck, Anna Greene, Daniel J. Buysse, Jennifer L. Steel

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective Sleep problems have been linked to increased risk of mortality in the general population. Limited evidence suggests similar relationships among people diagnosed with cancer. The aims of the present study were to investigate the type and rates of sleep problems in advanced cancer patients and examine whether sleep problems are associated with survival. Methods A prospective study of 292 patients with advanced cancers affecting the hepatobiliary and pancreatic systems were administered a battery of questionnaires measuring sociodemographic information, sleep, and depression. Descriptive statistics, ANOVA, Chi-square, Kaplan–Meier survival, and Cox regression analyses were performed to test the aims. Results The majority of patients were male (64%) and the mean age was 62 years (SD = 11). Fifty-nine percent of patients reported poor sleep quality; 43% reported sleeping ≤6 h and 2% ≥10 h; 40% reported sleep latency of 30 min or greater; average sleep efficiency was 80%. Of the 292 patients, 58% reported clinically levels of depression and depressive symptoms were related to shorter sleep duration (p = 0.02). After adjusting for factors known to contribute to survival, a curvilinear relationship was observed between sleep duration and mortality: short and long sleep duration were associated with increased mortality [linear term: hazard ratio (HR) = 0.485, 95% confidence interval (CI) = 0.275–0.857; quadratic term: HR = 1.064, 95% CI = 1.015–1.115]. Conclusions Consistent with findings in the general population, a curvilinear relationship between sleep duration and mortality was observed in advanced cancer patients. The high prevalence of sleep problems and link with mortality warrants routine screening and development of evidence-based treatments for sleep problems in the oncology setting.

Original languageEnglish (US)
Pages (from-to)208-212
Number of pages5
JournalSleep Medicine
Volume32
DOIs
StatePublished - Apr 1 2017

Fingerprint

Sleep
Survival
Neoplasms
Mortality
Depression
Confidence Intervals
Population
Analysis of Variance
Regression Analysis
Prospective Studies

Keywords

  • Cancer
  • Hepatobiliary
  • PSQI
  • Sleep
  • Sleep duration
  • Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Collins, K. P., Geller, D. A., Antoni, M. H., Donnell, D. M., Tsung, A., Marsh, J. W., ... Steel, J. L. (2017). Sleep duration is associated with survival in advanced cancer patients. Sleep Medicine, 32, 208-212. https://doi.org/10.1016/j.sleep.2016.06.041

Sleep duration is associated with survival in advanced cancer patients. / Collins, Kevin P.; Geller, David A.; Antoni, Michael H; Donnell, Drew Michael; Tsung, Allan; Marsh, James W.; Burke, Lora; Penedo, Frank; Terhorst, Lauren; Kamarck, Thomas W.; Greene, Anna; Buysse, Daniel J.; Steel, Jennifer L.

In: Sleep Medicine, Vol. 32, 01.04.2017, p. 208-212.

Research output: Contribution to journalArticle

Collins, KP, Geller, DA, Antoni, MH, Donnell, DM, Tsung, A, Marsh, JW, Burke, L, Penedo, F, Terhorst, L, Kamarck, TW, Greene, A, Buysse, DJ & Steel, JL 2017, 'Sleep duration is associated with survival in advanced cancer patients', Sleep Medicine, vol. 32, pp. 208-212. https://doi.org/10.1016/j.sleep.2016.06.041
Collins, Kevin P. ; Geller, David A. ; Antoni, Michael H ; Donnell, Drew Michael ; Tsung, Allan ; Marsh, James W. ; Burke, Lora ; Penedo, Frank ; Terhorst, Lauren ; Kamarck, Thomas W. ; Greene, Anna ; Buysse, Daniel J. ; Steel, Jennifer L. / Sleep duration is associated with survival in advanced cancer patients. In: Sleep Medicine. 2017 ; Vol. 32. pp. 208-212.
@article{9e5a33a66df34eca951e4ef1ef63792c,
title = "Sleep duration is associated with survival in advanced cancer patients",
abstract = "Objective Sleep problems have been linked to increased risk of mortality in the general population. Limited evidence suggests similar relationships among people diagnosed with cancer. The aims of the present study were to investigate the type and rates of sleep problems in advanced cancer patients and examine whether sleep problems are associated with survival. Methods A prospective study of 292 patients with advanced cancers affecting the hepatobiliary and pancreatic systems were administered a battery of questionnaires measuring sociodemographic information, sleep, and depression. Descriptive statistics, ANOVA, Chi-square, Kaplan–Meier survival, and Cox regression analyses were performed to test the aims. Results The majority of patients were male (64{\%}) and the mean age was 62 years (SD = 11). Fifty-nine percent of patients reported poor sleep quality; 43{\%} reported sleeping ≤6 h and 2{\%} ≥10 h; 40{\%} reported sleep latency of 30 min or greater; average sleep efficiency was 80{\%}. Of the 292 patients, 58{\%} reported clinically levels of depression and depressive symptoms were related to shorter sleep duration (p = 0.02). After adjusting for factors known to contribute to survival, a curvilinear relationship was observed between sleep duration and mortality: short and long sleep duration were associated with increased mortality [linear term: hazard ratio (HR) = 0.485, 95{\%} confidence interval (CI) = 0.275–0.857; quadratic term: HR = 1.064, 95{\%} CI = 1.015–1.115]. Conclusions Consistent with findings in the general population, a curvilinear relationship between sleep duration and mortality was observed in advanced cancer patients. The high prevalence of sleep problems and link with mortality warrants routine screening and development of evidence-based treatments for sleep problems in the oncology setting.",
keywords = "Cancer, Hepatobiliary, PSQI, Sleep, Sleep duration, Survival",
author = "Collins, {Kevin P.} and Geller, {David A.} and Antoni, {Michael H} and Donnell, {Drew Michael} and Allan Tsung and Marsh, {James W.} and Lora Burke and Frank Penedo and Lauren Terhorst and Kamarck, {Thomas W.} and Anna Greene and Buysse, {Daniel J.} and Steel, {Jennifer L.}",
year = "2017",
month = "4",
day = "1",
doi = "10.1016/j.sleep.2016.06.041",
language = "English (US)",
volume = "32",
pages = "208--212",
journal = "Sleep Medicine",
issn = "1389-9457",
publisher = "Elsevier",

}

TY - JOUR

T1 - Sleep duration is associated with survival in advanced cancer patients

AU - Collins, Kevin P.

AU - Geller, David A.

AU - Antoni, Michael H

AU - Donnell, Drew Michael

AU - Tsung, Allan

AU - Marsh, James W.

AU - Burke, Lora

AU - Penedo, Frank

AU - Terhorst, Lauren

AU - Kamarck, Thomas W.

AU - Greene, Anna

AU - Buysse, Daniel J.

AU - Steel, Jennifer L.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Objective Sleep problems have been linked to increased risk of mortality in the general population. Limited evidence suggests similar relationships among people diagnosed with cancer. The aims of the present study were to investigate the type and rates of sleep problems in advanced cancer patients and examine whether sleep problems are associated with survival. Methods A prospective study of 292 patients with advanced cancers affecting the hepatobiliary and pancreatic systems were administered a battery of questionnaires measuring sociodemographic information, sleep, and depression. Descriptive statistics, ANOVA, Chi-square, Kaplan–Meier survival, and Cox regression analyses were performed to test the aims. Results The majority of patients were male (64%) and the mean age was 62 years (SD = 11). Fifty-nine percent of patients reported poor sleep quality; 43% reported sleeping ≤6 h and 2% ≥10 h; 40% reported sleep latency of 30 min or greater; average sleep efficiency was 80%. Of the 292 patients, 58% reported clinically levels of depression and depressive symptoms were related to shorter sleep duration (p = 0.02). After adjusting for factors known to contribute to survival, a curvilinear relationship was observed between sleep duration and mortality: short and long sleep duration were associated with increased mortality [linear term: hazard ratio (HR) = 0.485, 95% confidence interval (CI) = 0.275–0.857; quadratic term: HR = 1.064, 95% CI = 1.015–1.115]. Conclusions Consistent with findings in the general population, a curvilinear relationship between sleep duration and mortality was observed in advanced cancer patients. The high prevalence of sleep problems and link with mortality warrants routine screening and development of evidence-based treatments for sleep problems in the oncology setting.

AB - Objective Sleep problems have been linked to increased risk of mortality in the general population. Limited evidence suggests similar relationships among people diagnosed with cancer. The aims of the present study were to investigate the type and rates of sleep problems in advanced cancer patients and examine whether sleep problems are associated with survival. Methods A prospective study of 292 patients with advanced cancers affecting the hepatobiliary and pancreatic systems were administered a battery of questionnaires measuring sociodemographic information, sleep, and depression. Descriptive statistics, ANOVA, Chi-square, Kaplan–Meier survival, and Cox regression analyses were performed to test the aims. Results The majority of patients were male (64%) and the mean age was 62 years (SD = 11). Fifty-nine percent of patients reported poor sleep quality; 43% reported sleeping ≤6 h and 2% ≥10 h; 40% reported sleep latency of 30 min or greater; average sleep efficiency was 80%. Of the 292 patients, 58% reported clinically levels of depression and depressive symptoms were related to shorter sleep duration (p = 0.02). After adjusting for factors known to contribute to survival, a curvilinear relationship was observed between sleep duration and mortality: short and long sleep duration were associated with increased mortality [linear term: hazard ratio (HR) = 0.485, 95% confidence interval (CI) = 0.275–0.857; quadratic term: HR = 1.064, 95% CI = 1.015–1.115]. Conclusions Consistent with findings in the general population, a curvilinear relationship between sleep duration and mortality was observed in advanced cancer patients. The high prevalence of sleep problems and link with mortality warrants routine screening and development of evidence-based treatments for sleep problems in the oncology setting.

KW - Cancer

KW - Hepatobiliary

KW - PSQI

KW - Sleep

KW - Sleep duration

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=85014471297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014471297&partnerID=8YFLogxK

U2 - 10.1016/j.sleep.2016.06.041

DO - 10.1016/j.sleep.2016.06.041

M3 - Article

C2 - 28366336

AN - SCOPUS:85014471297

VL - 32

SP - 208

EP - 212

JO - Sleep Medicine

JF - Sleep Medicine

SN - 1389-9457

ER -