Sleep disturbance mediates the association between psychological distress and immune status among HIV-positive men and women on combination antiretroviral therapy

Dean G. Cruess, Michael H Antoni, Jeffrey Gonzalez, Mary Ann Fletcher, Nancy Klimas, Ron Duran, Gail Ironson, Neil Schneiderman

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Objectives: This study examined the relationship between psychological distress, subjective sleep disturbance and immune status among HIV-positive men and women. Methods: Fifty-seven participants (41 men, 16 women) without AIDS-related illness and currently on combination antiretroviral therapy were recruited through community advertisement and physician referral. Participants completed the Impact of Events Scale (IBS) to assess symptoms of psychological distress and the Pittsburgh Sleep Quality Index (PSQI) to assess quality of sleep over the past month. T-lymphocyte subpopulations were also assessed from early morning blood samples. Results: Participants reporting greater psychological distress also reported more pronounced sleep disruption. Higher levels of distress and greater sleep disturbance were also significantly related to lower T-cytotoxic/suppressor (CD3 + CD8+) cell counts. Path analysis revealed that the association between distress level and CDS + CD8+ cell counts was mediated by poorer subjective sleep quality. Conclusions: These findings suggest that psychological distress may impact upon the immune system through its effects on sleep quality.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalJournal of Psychosomatic Research
Volume54
Issue number3
DOIs
StatePublished - Mar 1 2003

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Sleep
HIV
Psychology
Therapeutics
Cell Count
Lymphocyte Subsets
Immune System
Acquired Immunodeficiency Syndrome
Referral and Consultation
Physicians
T-Lymphocytes

Keywords

  • Distress
  • HIV
  • Immune
  • Sleep

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Sleep disturbance mediates the association between psychological distress and immune status among HIV-positive men and women on combination antiretroviral therapy. / Cruess, Dean G.; Antoni, Michael H; Gonzalez, Jeffrey; Fletcher, Mary Ann; Klimas, Nancy; Duran, Ron; Ironson, Gail; Schneiderman, Neil.

In: Journal of Psychosomatic Research, Vol. 54, No. 3, 01.03.2003, p. 185-189.

Research output: Contribution to journalArticle

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AU - Duran, Ron

AU - Ironson, Gail

AU - Schneiderman, Neil

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