Skin pH: From basic science to basic skin care

Saba M. Ali, Gil Yosipovitch

Research output: Contribution to journalReview articlepeer-review

252 Scopus citations


The "acid mantle" is a topic not only of historical interest, but also of clinical signifcance and has recently been linked to vital stratum corneum function. Despite compelling basic science evidence placing skin pH as a key factor in barrier homeostasis, stratum corneum integrity, and antimicrobial defense, application of the acid mantle concept in clinical care is lacking. We review recent basic science investigations into skin pH, discuss skin disorders characterized by aberrant pH, and fnally discuss practical application for preservation of the acid mantle. Recognizing factors that alter skin pH and selecting products that preserve the acid mantle is of prime importance in treating dermatologic patients.

Original languageEnglish (US)
Pages (from-to)261-267
Number of pages7
JournalActa dermato-venereologica
Issue number3
StatePublished - Mar 2013
Externally publishedYes


  • Acid mantle
  • Acne
  • Atopic dermatitis
  • Barrier homeosta-sis
  • Diaper dermatitis
  • Intertrigo
  • Serine protease
  • Skin pH
  • Stratum corneum
  • Syndets

ASJC Scopus subject areas

  • Dermatology


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