Abstract
The "acid mantle" is a topic not only of historical interest, but also of clinical signifcance and has recently been linked to vital stratum corneum function. Despite compelling basic science evidence placing skin pH as a key factor in barrier homeostasis, stratum corneum integrity, and antimicrobial defense, application of the acid mantle concept in clinical care is lacking. We review recent basic science investigations into skin pH, discuss skin disorders characterized by aberrant pH, and fnally discuss practical application for preservation of the acid mantle. Recognizing factors that alter skin pH and selecting products that preserve the acid mantle is of prime importance in treating dermatologic patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 261-267 |
| Number of pages | 7 |
| Journal | Acta dermato-venereologica |
| Volume | 93 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2013 |
Keywords
- Acid mantle
- Acne
- Atopic dermatitis
- Barrier homeosta-sis
- Diaper dermatitis
- Intertrigo
- Serine protease
- Skin pH
- Stratum corneum
- Syndets
ASJC Scopus subject areas
- Dermatology