Skin necrosis unrelated to injection sites after heparin administration

Skin necrosis is a rare side effect of heparin therapy that is usually localized at injection sites. A 79-year-old patient developed severe thrombocytopenia and extensive skin necrosis unrelated to injection sites after subcutaneous administration of heparin. Although heparin therapy was discontinued, the patient died few days later following myocardial infarction. To our knowledge this is the 2nd reported case of skin necrosis after subcutaneous administration of heparin unrelated to injection sites.