Skin barrier damage and itch: Review of mechanisms, topical management and future directions

Gil Yosipovitch, Laurent Misery, Ehrhardt Proksch, Martin Metz, Sonja Ständer, Martin Schmelz

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Barrier damage, dry skin and itch are intricately linked and form the basis of many common skin diseases. Damage from environmental insults, or genetic or inflammatory causes, can impair the skin barrier, resulting in an increase in transepidermal water loss and activation of itch-associated nerve fibres. The itch–scratch cycle can perpetuate skin barrier damage and itch. Topical therapeutic strategies are utilised to overcome dry skin and itch, primarily in the form of emollients. Recent advances in our understanding of the mechanisms underlying itch have enabled the development of new topical therapies, which may be incorporated into existing treatment regimes. Ultimately, treatment of dry skin and itch must be highly tailored to the individual according to their needs.

Original languageEnglish (US)
Pages (from-to)1201-1209
Number of pages9
JournalActa dermato-venereologica
Volume99
Issue number13
DOIs
StatePublished - 2019

Keywords

  • Dry skin
  • Emollients
  • Pruritus
  • Skin barrier

ASJC Scopus subject areas

  • Dermatology

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