@article{de8203b9fa0a4890b64882dd9ac5ff7a,
title = "Skin barrier damage and itch: Review of mechanisms, topical management and future directions",
abstract = "Barrier damage, dry skin and itch are intricately linked and form the basis of many common skin diseases. Damage from environmental insults, or genetic or inflammatory causes, can impair the skin barrier, resulting in an increase in transepidermal water loss and activation of itch-associated nerve fibres. The itch–scratch cycle can perpetuate skin barrier damage and itch. Topical therapeutic strategies are utilised to overcome dry skin and itch, primarily in the form of emollients. Recent advances in our understanding of the mechanisms underlying itch have enabled the development of new topical therapies, which may be incorporated into existing treatment regimes. Ultimately, treatment of dry skin and itch must be highly tailored to the individual according to their needs.",
keywords = "Dry skin, Emollients, Pruritus, Skin barrier",
author = "Gil Yosipovitch and Laurent Misery and Ehrhardt Proksch and Martin Metz and Sonja St{\"a}nder and Martin Schmelz",
note = "Funding Information: Johnson, Leo Pharma, Eli Lilly, Menlo Therapeutics, Nestl{\'e} Skin Health, Novartis, Pierre Fabre, Pfizer, La Roche-Posay, Sanofi, Solabia, Trevi Therapeutics, UCB and Uriage. MM has been a consultant and/or advisory board member for Bayer, Beiersdorf, Celgene, Menlo Therapeutics, Merz Pharma, Novartis, NeRRe, Pierre Fabre, Roche, Sanofi and Sienna Biopharmaceuticals. EP has taken part in an expert panel organised by Bayer Consumer Health. SS has taken part in advisory boards organised by Sienna Therapeutics, Bayer, Celgene and Menlo Therapeutics, received research funding from Menlo Therapeutics, Dermasence, Trevi Therapeutics, Galderma, Novartis and Kiniksa, and received consulting fees from Beiersdorf, Celgene, NeRRe Therapeutics, Sienna Therapeutics, ACO HUD Nordic, Cemka, Trevi Therapeutics and Menlo Therapeutics. MS has taken part in an expert panel organised by Bayer Consumer Health. Publisher Copyright: {\textcopyright} 2019 Acta Dermato-Venereologica.",
year = "2019",
doi = "10.2340/00015555-3296",
language = "English (US)",
volume = "99",
pages = "1201--1209",
journal = "Acta Dermato-Venereologica",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato-Venereologica",
number = "13",
}