Skin as an endocrine organ: implications for its function

Andrzej Slominski; Jacobo Wortsman; Ralf Paus; Peter M. Elias; Desmond J. Tobin; Kenneth R. Feingold

doi:10.1016/j.ddmec.2008.04.004

Skin as an endocrine organ: implications for its function

Andrzej Slominski, Jacobo Wortsman, Ralf Paus, Peter M. Elias, Desmond J. Tobin, Kenneth R. Feingold

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

Described as the body's largest organ, the skin is strategically located at the interface with the external environment where it has evolved to detect, integrate and respond to a diverse range of stressors. A flurry of recent findings has established the skin as an important peripheral (neuro)endocrine organ that is tightly networked to central stress axes. This capability is contributing to the maintenance of body homeostasis, and in this way could be harnessed for therapeutic strategies.

Original language	English (US)
Pages (from-to)	e137-e144
Journal	Drug Discovery Today: Disease Mechanisms
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/j.ddmec.2008.04.004
State	Published - Jun 2008
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddmec.2008.04.004

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title = "Skin as an endocrine organ: implications for its function",

abstract = "Described as the body's largest organ, the skin is strategically located at the interface with the external environment where it has evolved to detect, integrate and respond to a diverse range of stressors. A flurry of recent findings has established the skin as an important peripheral (neuro)endocrine organ that is tightly networked to central stress axes. This capability is contributing to the maintenance of body homeostasis, and in this way could be harnessed for therapeutic strategies.",

author = "Andrzej Slominski and Jacobo Wortsman and Ralf Paus and Elias, {Peter M.} and Tobin, {Desmond J.} and Feingold, {Kenneth R.}",

note = "Funding Information: We are most grateful to Drs T. and N. Ito for preparing Fig. 2 (based on Ref. [ 21 ]) and Dr Jean Rivier for his comments on CRF1 antagonists. Writing of this review was supported partly by NIH grants # AR052190 (AS), AR047079 (AS and DT), AR049932 (KRF), and by a grant from DFG to RP (Pa 345/11-2).",

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T2 - implications for its function

AU - Slominski, Andrzej

AU - Wortsman, Jacobo

AU - Paus, Ralf

AU - Elias, Peter M.

AU - Tobin, Desmond J.

AU - Feingold, Kenneth R.

N1 - Funding Information: We are most grateful to Drs T. and N. Ito for preparing Fig. 2 (based on Ref. [ 21 ]) and Dr Jean Rivier for his comments on CRF1 antagonists. Writing of this review was supported partly by NIH grants # AR052190 (AS), AR047079 (AS and DT), AR049932 (KRF), and by a grant from DFG to RP (Pa 345/11-2).

PY - 2008/6

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N2 - Described as the body's largest organ, the skin is strategically located at the interface with the external environment where it has evolved to detect, integrate and respond to a diverse range of stressors. A flurry of recent findings has established the skin as an important peripheral (neuro)endocrine organ that is tightly networked to central stress axes. This capability is contributing to the maintenance of body homeostasis, and in this way could be harnessed for therapeutic strategies.

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