Skin as an endocrine organ: implications for its function

Andrzej Slominski, Jacobo Wortsman, Ralf Paus, Peter M. Elias, Desmond J. Tobin, Kenneth R. Feingold

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations


Described as the body's largest organ, the skin is strategically located at the interface with the external environment where it has evolved to detect, integrate and respond to a diverse range of stressors. A flurry of recent findings has established the skin as an important peripheral (neuro)endocrine organ that is tightly networked to central stress axes. This capability is contributing to the maintenance of body homeostasis, and in this way could be harnessed for therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)e137-e144
JournalDrug Discovery Today: Disease Mechanisms
Issue number2
StatePublished - Jun 2008
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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