TY - JOUR
T1 - Skin as an endocrine organ
T2 - implications for its function
AU - Slominski, Andrzej
AU - Wortsman, Jacobo
AU - Paus, Ralf
AU - Elias, Peter M.
AU - Tobin, Desmond J.
AU - Feingold, Kenneth R.
N1 - Funding Information:
We are most grateful to Drs T. and N. Ito for preparing Fig. 2 (based on Ref. [ 21 ]) and Dr Jean Rivier for his comments on CRF1 antagonists. Writing of this review was supported partly by NIH grants # AR052190 (AS), AR047079 (AS and DT), AR049932 (KRF), and by a grant from DFG to RP (Pa 345/11-2).
PY - 2008/6
Y1 - 2008/6
N2 - Described as the body's largest organ, the skin is strategically located at the interface with the external environment where it has evolved to detect, integrate and respond to a diverse range of stressors. A flurry of recent findings has established the skin as an important peripheral (neuro)endocrine organ that is tightly networked to central stress axes. This capability is contributing to the maintenance of body homeostasis, and in this way could be harnessed for therapeutic strategies.
AB - Described as the body's largest organ, the skin is strategically located at the interface with the external environment where it has evolved to detect, integrate and respond to a diverse range of stressors. A flurry of recent findings has established the skin as an important peripheral (neuro)endocrine organ that is tightly networked to central stress axes. This capability is contributing to the maintenance of body homeostasis, and in this way could be harnessed for therapeutic strategies.
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U2 - 10.1016/j.ddmec.2008.04.004
DO - 10.1016/j.ddmec.2008.04.004
M3 - Review article
AN - SCOPUS:55249114278
VL - 5
SP - e137-e144
JO - Drug Discovery Today: Disease Mechanisms
JF - Drug Discovery Today: Disease Mechanisms
SN - 1740-6765
IS - 2
ER -