Skeletal maturation and predicted adult height in children with premature adrenarche

Shilpa Gurnurkar, Kristopher L. Arheart, Sarah E. Messiah, Aimee Mankodi, Adriana Carrillo

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objective: Premature adrenarche (PA) may be associated with obesity and advanced bone age. Our objective was to determine if children with PA had a predicted adult height less than target height. Methods: A retrospective chart review identified 100 children originating predominantly from South and Central America and the Caribbean region previously diagnosed with PA from one pediatric endocrinology clinic. Results: The majority (89.2%) of the sample had advanced bone age, while 43.4% were obese and 41.8% had a predicted height below target. There was a significant correlation between body mass index Z-score and bone age advancement among boys (r = 0.67, p < 0.001). The majority (72.7%) of those with a predicted height below target had a bone age advancement of two standard deviations or more. Conclusions: These findings suggest that PA and obesity are associated with rapid skeletal maturation and that significant bone age advancement in PA is associated with a sub-optimal adult height.

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Volume27
Issue number1-2
DOIs
StatePublished - Jan 1 2014

Keywords

  • Bone age
  • Obesity
  • Predicted adult height
  • Premature adrenarche

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

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