Size-dependent intranasal administration of magnetoelectric nanoparticles for targeted brain localization

Marta Pardo, Evan R. Roberts, Krystine Pimentel, Yagmur Akin Yildirim, Brayan Navarrete, Ping Wang, Elric Zhang, Ping Liang, Sakhrat Khizroev

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The brain is a massive network of neurons which are interconnected through chemical and electrical field oscillations. It is hard to overestimate the significance of the ability to control chemical and physical properties of the network at both the collective and single-cell levels. Most psychiatric and neurodegenerative diseases are typically characterized by certain aberrations of these oscillations. Recently, magnetoelectric nanoparticles (MENs) have been introduced to achieve the desired control. MENs effectively enable wirelessly controlled nanoelectrodes deep in the brain. Although MENs have been shown to cross the blood–brain barrier via intravenous (IV) administration, achieving adequate efficacy of the delivery remains an open question. Herein, through in vivo studies on a mouse model, we demonstrate at least a 4-fold improved efficacy of the targeted delivery of MENs across BBB via intranasal administration compared to an equivalent IV administration.

Original languageEnglish (US)
Article number102337
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume32
DOIs
StatePublished - Feb 2021

Keywords

  • Blood brain barrier crossing
  • Intranasal administration
  • Magnetoelectric nanoparticles
  • Nanoneuromedicines

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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