Sites of paradoxical action of the LHRH agonist (D-Trp6)-LHRH

A. Arimura, S. Talbot, P. C. Serafini, A. V. Schally

Research output: Contribution to journalArticle

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Abstract

Immature intact and hypophysectomized female rats, which were primed with gonadotropin, were injected subcutaneously with 0.9% saline or 0.2 or 2 μg of (D-Trp6)-LHRH once daily for 7 days. Ovarian LH/hCG receptors and ovarian weight were measured 24 hours after the last analog or saline injection. A significant reduction (P < 0.01) of ovarian LH/hCG receptors in both intact and hypophysectomized rats was observed following administration of (D-Trp6)-LHRH may indicate that the analog has a direct effect on the ovaries.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalInternational Journal of Fertility
Volume25
Issue number3
StatePublished - Dec 1 1980
Externally publishedYes

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ASJC Scopus subject areas

  • Obstetrics and Gynecology

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