Site-specific recombination on unknot and unlink substrates producing two-bridge links

Research output: Chapter in Book/Report/Conference proceedingChapter


Site-specific recombinases act upon circular DNA, transforming it from one conformation into another. Keeping track of just the axial backbone of the DNA, we may represent the DNA as topological knots and links and model the transformations as localized bandings. As single unknotted loops of DNA and pairs of unlinked unknotted loops of DNA are the typical substrates generated in the laboratory for recombination, and two-bridge links are among the more common conformations arising from recombination, we survey both the classification of which two-bridge links may be thus obtained and the current state of knowledge about where these transformations may occur.

Original languageEnglish (US)
Title of host publicationNatural Computing Series
PublisherSpringer Verlag
Number of pages24
StatePublished - 2014

Publication series

NameNatural Computing Series
ISSN (Print)1619-7127

ASJC Scopus subject areas

  • Software
  • Theoretical Computer Science


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