Site nurse-initiated adherence and symptom support telephone calls for HIV-positive individuals starting antiretroviral therapy, ACTG 5031

Substudy of ACTG 384

Gregory Robbins, Marcia Testa, Max Su, Steven Safren, Gene Morse, Sara Lammert, Robert Shafer, Nancy Reynolds, Margaret Chesney

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Effective and easy to implement interventions to improve adherence to antiretroviral therapy are needed. Objective: To compare site nurse-initiated adherence and symptom support telephone calls for HIV-positive individuals starting antiretroviral therapy to the study site's standard of care. Methods: A randomized controlled trial of site nurse-initiated adherence and symptom support telephone calls for HIV-positive individuals starting antiretroviral therapy. Subjects were randomized to receive site nurse-initiated telephone calls (intervention) or no additional calls to the site's standard of care (control). Subjects received calls 1 to 3 days after initiating antiretrovirals, on weeks 1, 2, 3, 6, 10, 14, 18, 22, and 26, and every 8 weeks thereafter. Self-reported adherence was captured during study visits. Results: A total of 333 subjects starting antiretrovirals as part of ACTG 384 were co-enrolled into ACTG 5031. Subjects were followed for up to 160 weeks and were contacted for 74% of scheduled calls. There was no significant difference in proportion of patients with â‰̄95% mean total adherence (87.9% and 91.2%; P = .34) and mean self-reported total adherence (97.9% and 98.4%) in the intervention and control groups, respectively, or in symptom distress and clinical endpoints. Conclusions: In the context of a clinical trial where self-reported adherence was exceptionally high, the site nurse-initiated telephone calls did not further improve self-reported adherence, symptom distress, or clinical outcomes.

Original languageEnglish (US)
Pages (from-to)235-253
Number of pages19
JournalHIV Clinical Trials
Volume14
Issue number5
DOIs
StatePublished - 2013
Externally publishedYes

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Telephone
Nurses
HIV
Standard of Care
Therapeutics
Randomized Controlled Trials
Clinical Trials
Control Groups

Keywords

  • adherence intervention
  • antiretroviral therapy
  • human immunodeficiency virus (HIV)
  • nursing telephone support
  • randomized controlled trial

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Site nurse-initiated adherence and symptom support telephone calls for HIV-positive individuals starting antiretroviral therapy, ACTG 5031 : Substudy of ACTG 384. / Robbins, Gregory; Testa, Marcia; Su, Max; Safren, Steven; Morse, Gene; Lammert, Sara; Shafer, Robert; Reynolds, Nancy; Chesney, Margaret.

In: HIV Clinical Trials, Vol. 14, No. 5, 2013, p. 235-253.

Research output: Contribution to journalArticle

Robbins, Gregory ; Testa, Marcia ; Su, Max ; Safren, Steven ; Morse, Gene ; Lammert, Sara ; Shafer, Robert ; Reynolds, Nancy ; Chesney, Margaret. / Site nurse-initiated adherence and symptom support telephone calls for HIV-positive individuals starting antiretroviral therapy, ACTG 5031 : Substudy of ACTG 384. In: HIV Clinical Trials. 2013 ; Vol. 14, No. 5. pp. 235-253.
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