Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition

Raffaele Palmirotta, Mauro Cives, David Della Morte, Barbara Capuani, Davide Lauro, Fiorella Guadagni, Franco Silvestris

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

The human sirtuins (SIRT1-SIRT7) enzymes are a highly conserved family of NAD+-dependent histone deacetylases, which play a critical role in the regulation of a large number of metabolic pathways involved in stress response and aging. Cancer is an age-Associated disease, and sirtuins may have a considerable impact on a plethora of processes that regulate tumorigenesis. In particular, growing evidence suggests that sirtuins may modulate epithelial plasticity by inducing transcriptional reprogramming leading to epithelial-mesenchymal transition (EMT), invasion, and metastases. Though commonly regarded as EMT inducers, sirtuins may also suppress this process, and their functional properties seem to largely depend on the cellular context, stage of cancer development, tissue of origin, and microenvironment architecture. Here, we review the role of sirtuins in cancer biology with particular emphasis on their role in EMT.

Original languageEnglish (US)
Article number3031459
JournalOxidative Medicine and Cellular Longevity
Volume2016
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Sirtuins
Epithelial-Mesenchymal Transition
Neoplasms
Group III Histone Deacetylases
Metabolic Networks and Pathways
Plasticity
Carcinogenesis
Aging of materials
Tissue
Neoplasm Metastasis
Enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Cell Biology

Cite this

Palmirotta, R., Cives, M., Della Morte, D., Capuani, B., Lauro, D., Guadagni, F., & Silvestris, F. (2016). Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition. Oxidative Medicine and Cellular Longevity, 2016, [3031459]. https://doi.org/10.1155/2016/3031459

Sirtuins and Cancer : Role in the Epithelial-Mesenchymal Transition. / Palmirotta, Raffaele; Cives, Mauro; Della Morte, David; Capuani, Barbara; Lauro, Davide; Guadagni, Fiorella; Silvestris, Franco.

In: Oxidative Medicine and Cellular Longevity, Vol. 2016, 3031459, 01.01.2016.

Research output: Contribution to journalReview article

Palmirotta, R, Cives, M, Della Morte, D, Capuani, B, Lauro, D, Guadagni, F & Silvestris, F 2016, 'Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition', Oxidative Medicine and Cellular Longevity, vol. 2016, 3031459. https://doi.org/10.1155/2016/3031459
Palmirotta, Raffaele ; Cives, Mauro ; Della Morte, David ; Capuani, Barbara ; Lauro, Davide ; Guadagni, Fiorella ; Silvestris, Franco. / Sirtuins and Cancer : Role in the Epithelial-Mesenchymal Transition. In: Oxidative Medicine and Cellular Longevity. 2016 ; Vol. 2016.
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