TY - JOUR
T1 - SIRT2 as a new player in epigenetic programming of keratinocyte differentiation and a candidate tumor suppressor
AU - Wang, Ming
AU - Yue, Zhicao
AU - Paus, Ralf
AU - Ramot, Yuval
N1 - Publisher Copyright:
© 2014 John Wiley & Sons A/S.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Epidermal keratinocytes undergo a continuous process of terminal differentiation, which is accompanied by a dramatic change in the expression and composition of keratins. This complex and carefully orchestrated process is regulated by a large number of signal transduction events and transcriptional factors as well as by epigenetic regulatory mechanisms, namely by histone methylation/acetylation and DNA methylation. In a recent issue of Exp Dermatol, Ming et al. provide evidence that sirtuin-2 (SIRT2), a NAD+-dependent deacetylase, inhibits the expression of keratin 15 and keratin 19, epidermal stem cell markers, while it stimulates the expression of loricrin, a marker of terminal keratinocyte differentiation. Human skin cancer cells show downregulation of SIRT2, and its deletion increases tumor growth in mice. Overall, these findings suggest that this deacetylase is involved in the epigenetic regulation of keratinocyte differentiation and exerts intracutaneous tumor suppressor functions.
AB - Epidermal keratinocytes undergo a continuous process of terminal differentiation, which is accompanied by a dramatic change in the expression and composition of keratins. This complex and carefully orchestrated process is regulated by a large number of signal transduction events and transcriptional factors as well as by epigenetic regulatory mechanisms, namely by histone methylation/acetylation and DNA methylation. In a recent issue of Exp Dermatol, Ming et al. provide evidence that sirtuin-2 (SIRT2), a NAD+-dependent deacetylase, inhibits the expression of keratin 15 and keratin 19, epidermal stem cell markers, while it stimulates the expression of loricrin, a marker of terminal keratinocyte differentiation. Human skin cancer cells show downregulation of SIRT2, and its deletion increases tumor growth in mice. Overall, these findings suggest that this deacetylase is involved in the epigenetic regulation of keratinocyte differentiation and exerts intracutaneous tumor suppressor functions.
KW - Epigenetic programming
KW - Keratinocyte differentiation
KW - SIRT2
UR - http://www.scopus.com/inward/record.url?scp=84921905787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84921905787&partnerID=8YFLogxK
U2 - 10.1111/exd.12434
DO - 10.1111/exd.12434
M3 - Comment/debate
C2 - 24814870
AN - SCOPUS:84921905787
VL - 23
SP - 636
EP - 638
JO - Experimental Dermatology
JF - Experimental Dermatology
SN - 0906-6705
IS - 9
ER -