Sirt1: A metabolic master switch that modulates lifespan

Ingo B. Leibiger, Per Olof Berggren

Research output: Contribution to journalShort surveypeer-review

101 Scopus citations


Sirt1, an enzyme that removes acetyl groups from specific nuclear proteins, has been linked to the regulation of aging. It is now clear that Sirt1 also controls hepatic glucose metabolism by serving as a sensor of the metabolic status in hepatocytes.

Original languageEnglish (US)
Pages (from-to)34-36
Number of pages3
JournalNature medicine
Issue number1
StatePublished - Jan 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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