Sirt1

A metabolic master switch that modulates lifespan

Ingo B. Leibiger, Per Olof Berggren

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Sirt1, an enzyme that removes acetyl groups from specific nuclear proteins, has been linked to the regulation of aging. It is now clear that Sirt1 also controls hepatic glucose metabolism by serving as a sensor of the metabolic status in hepatocytes.

Original languageEnglish
Pages (from-to)34-36
Number of pages3
JournalNature Medicine
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

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Nuclear Proteins
Metabolism
Hepatocytes
Aging of materials
Switches
Glucose
Liver
Sensors
Enzymes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Sirt1 : A metabolic master switch that modulates lifespan. / Leibiger, Ingo B.; Berggren, Per Olof.

In: Nature Medicine, Vol. 12, No. 1, 01.01.2006, p. 34-36.

Research output: Contribution to journalArticle

Leibiger, Ingo B. ; Berggren, Per Olof. / Sirt1 : A metabolic master switch that modulates lifespan. In: Nature Medicine. 2006 ; Vol. 12, No. 1. pp. 34-36.
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