Sinus histiocytosis with massive lymphadenopathy. A case with unusual skin involvement and a therapeutic response to vinblastine‐loaded platelets

Neal S. Penneys; Yeon S. Ahn; E. Churchill McKinney; Thomas McCleod; Gerald Byrne; John Byrnes; Mehrdad Nadji

doi:10.1002/1097-0142(19820515)49:10<1994::AID-CNCR2820491008>3.0.CO;2-T

Sinus histiocytosis with massive lymphadenopathy. A case with unusual skin involvement and a therapeutic response to vinblastine‐loaded platelets

Neal S. Penneys, Yeon S. Ahn, E. Churchill McKinney, Thomas McCleod, Gerald Byrne, John Byrnes, Mehrdad Nadji

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A patient with sinus histiocytosis with massive lymphadenopathy had unusual skin lesions and progressive internal involvement. Both aspects responded dramatically to the administration of vinblastine-loaded platelets. Vinblastine-loaded, idiopathic thrombocytopenic purpura antibody-coated platelets are a rationale therapy for a disease characterized by the presence of actively phagocytosing histiocytes.

Original language	English (US)
Pages (from-to)	1994-1998
Number of pages	5
Journal	Cancer
Volume	49
Issue number	10
DOIs	https://doi.org/10.1002/1097-0142(19820515)49:10<1994::AID-CNCR2820491008>3.0.CO;2-T
State	Published - May 15 1982

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19820515)49:10<1994::AID-CNCR2820491008>3.0.CO;2-T

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Sinus histiocytosis with massive lymphadenopathy. A case with unusual skin involvement and a therapeutic response to vinblastine‐loaded platelets. / Penneys, Neal S.; Ahn, Yeon S.; Churchill McKinney, E.; McCleod, Thomas; Byrne, Gerald; Byrnes, John ; Nadji, Mehrdad.

In: Cancer, Vol. 49, No. 10, 15.05.1982, p. 1994-1998.

Research output: Contribution to journal › Article › peer-review

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AU - Byrnes, John

AU - Nadji, Mehrdad

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AB - A patient with sinus histiocytosis with massive lymphadenopathy had unusual skin lesions and progressive internal involvement. Both aspects responded dramatically to the administration of vinblastine-loaded platelets. Vinblastine-loaded, idiopathic thrombocytopenic purpura antibody-coated platelets are a rationale therapy for a disease characterized by the presence of actively phagocytosing histiocytes.

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Sinus histiocytosis with massive lymphadenopathy. A case with unusual skin involvement and a therapeutic response to vinblastine‐loaded platelets

Abstract

ASJC Scopus subject areas

UN SDGs

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