Sinoaortic denervation does not prevent differential Pavlovian conditioning of bradycardia in rabbits

Theodore W. Jarrell, Christopher G. Gentile, Philip McCabe, Neil Schneiderman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Recent findings suggest that descending projections from the amygdaloid central nucleus of the solitary tract (NTS) may modulate the baroreceptor reflex and thereby facilitate the expression of the bradycardiac conditioned response (CR) in rabbits18,21. The purpose of the present study was to examine the role of the afferent limb of the baroreceptor reflex in differential Pavlovian conditioning of bradycardia in rabbits. Animals received either aortic denervation, sinoaortic denervation or sham denervation. After recovery from surgery, animals received one differential Pavlovian conditioning session per day over the nex 6 days. Sinoaortic denervation abolished the baroreceptor reflex as assessed by intravenous injections of phenylephrine. In addition, sinoaortic denervation increased baseline heart rate (HR), altered the topography of the HR unconditioned response, but did not abolish the HR orienting response or prevent the acquisition of bradycardiac CRs. The findings of the present study suggest that afferent barosensory input is not necessary for the expression of the HR CR in rabbits. However, descending ACE projections may stil play a role in the HC CR by directly affecting NTS neurons.

Original languageEnglish
Pages (from-to)251-258
Number of pages8
JournalBrain Research
Volume381
Issue number2
DOIs
StatePublished - Sep 3 1986

Fingerprint

Denervation
Bradycardia
Baroreflex
Rabbits
Heart Rate
Solitary Nucleus
Phenylephrine
Intravenous Injections
Extremities
Neurons

Keywords

  • baroreceptor reflex
  • bradycardia
  • differential pavlovian conditioning
  • rabbit
  • sinoaortic denervation

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Sinoaortic denervation does not prevent differential Pavlovian conditioning of bradycardia in rabbits. / Jarrell, Theodore W.; Gentile, Christopher G.; McCabe, Philip; Schneiderman, Neil.

In: Brain Research, Vol. 381, No. 2, 03.09.1986, p. 251-258.

Research output: Contribution to journalArticle

@article{d23821db16ca43daa9335cf427afd81e,
title = "Sinoaortic denervation does not prevent differential Pavlovian conditioning of bradycardia in rabbits",
abstract = "Recent findings suggest that descending projections from the amygdaloid central nucleus of the solitary tract (NTS) may modulate the baroreceptor reflex and thereby facilitate the expression of the bradycardiac conditioned response (CR) in rabbits18,21. The purpose of the present study was to examine the role of the afferent limb of the baroreceptor reflex in differential Pavlovian conditioning of bradycardia in rabbits. Animals received either aortic denervation, sinoaortic denervation or sham denervation. After recovery from surgery, animals received one differential Pavlovian conditioning session per day over the nex 6 days. Sinoaortic denervation abolished the baroreceptor reflex as assessed by intravenous injections of phenylephrine. In addition, sinoaortic denervation increased baseline heart rate (HR), altered the topography of the HR unconditioned response, but did not abolish the HR orienting response or prevent the acquisition of bradycardiac CRs. The findings of the present study suggest that afferent barosensory input is not necessary for the expression of the HR CR in rabbits. However, descending ACE projections may stil play a role in the HC CR by directly affecting NTS neurons.",
keywords = "baroreceptor reflex, bradycardia, differential pavlovian conditioning, rabbit, sinoaortic denervation",
author = "Jarrell, {Theodore W.} and Gentile, {Christopher G.} and Philip McCabe and Neil Schneiderman",
year = "1986",
month = "9",
day = "3",
doi = "10.1016/0006-8993(86)90074-0",
language = "English",
volume = "381",
pages = "251--258",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Sinoaortic denervation does not prevent differential Pavlovian conditioning of bradycardia in rabbits

AU - Jarrell, Theodore W.

AU - Gentile, Christopher G.

AU - McCabe, Philip

AU - Schneiderman, Neil

PY - 1986/9/3

Y1 - 1986/9/3

N2 - Recent findings suggest that descending projections from the amygdaloid central nucleus of the solitary tract (NTS) may modulate the baroreceptor reflex and thereby facilitate the expression of the bradycardiac conditioned response (CR) in rabbits18,21. The purpose of the present study was to examine the role of the afferent limb of the baroreceptor reflex in differential Pavlovian conditioning of bradycardia in rabbits. Animals received either aortic denervation, sinoaortic denervation or sham denervation. After recovery from surgery, animals received one differential Pavlovian conditioning session per day over the nex 6 days. Sinoaortic denervation abolished the baroreceptor reflex as assessed by intravenous injections of phenylephrine. In addition, sinoaortic denervation increased baseline heart rate (HR), altered the topography of the HR unconditioned response, but did not abolish the HR orienting response or prevent the acquisition of bradycardiac CRs. The findings of the present study suggest that afferent barosensory input is not necessary for the expression of the HR CR in rabbits. However, descending ACE projections may stil play a role in the HC CR by directly affecting NTS neurons.

AB - Recent findings suggest that descending projections from the amygdaloid central nucleus of the solitary tract (NTS) may modulate the baroreceptor reflex and thereby facilitate the expression of the bradycardiac conditioned response (CR) in rabbits18,21. The purpose of the present study was to examine the role of the afferent limb of the baroreceptor reflex in differential Pavlovian conditioning of bradycardia in rabbits. Animals received either aortic denervation, sinoaortic denervation or sham denervation. After recovery from surgery, animals received one differential Pavlovian conditioning session per day over the nex 6 days. Sinoaortic denervation abolished the baroreceptor reflex as assessed by intravenous injections of phenylephrine. In addition, sinoaortic denervation increased baseline heart rate (HR), altered the topography of the HR unconditioned response, but did not abolish the HR orienting response or prevent the acquisition of bradycardiac CRs. The findings of the present study suggest that afferent barosensory input is not necessary for the expression of the HR CR in rabbits. However, descending ACE projections may stil play a role in the HC CR by directly affecting NTS neurons.

KW - baroreceptor reflex

KW - bradycardia

KW - differential pavlovian conditioning

KW - rabbit

KW - sinoaortic denervation

UR - http://www.scopus.com/inward/record.url?scp=0022497070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022497070&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(86)90074-0

DO - 10.1016/0006-8993(86)90074-0

M3 - Article

C2 - 3756502

AN - SCOPUS:0022497070

VL - 381

SP - 251

EP - 258

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -