Single shot T magnetic resonance imaging of metabolically generated water in vivo

Eric A. Mellon, R. Shashank Beesam, Mallikarjunarao Kasam, James E. Baumgardner, Arijitt Borthakur, Walter R. Witschey, Ravinder Reddy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

The use of Oxygen-17 MRI provides great promise for the clinically-useful quantification of metabolism. To bring techniques based on 17O closer to clinical application, we demonstrate imaging of metabolically generated H217O in pigs after 17O2 delivery with increased temporal resolution T-weighted imaging and precision delivery of 17O2 gas. The kinetics of the appearance of H217O in pig brains are displayed with one to two minutes of 17O2 delivery, the shortest delivery times reported in the literature. It is also shown that H2 17O concentrations can be quantified with single shot T imaging based on a balanced steady state free precession readout, and that with this strategy pausing to reduce T1 saturation increases sensitivity to H217O over acquisition in the steady state. Several additional considerations with this sequence, which can be generalized to any pre-encoding cluster, such as energy deposition are considered.

Original languageEnglish (US)
Title of host publicationOxygen Transport to Tissue XXX
EditorsPer Liss, Peter Hansell, Duane Bruley, David Harrison
Pages279-286
Number of pages8
DOIs
StatePublished - 2009
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume645
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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