Single-dose intramuscular methotrexate treatment of cervical ectopic pregnancy: A case report

Albert Asante, Usha Verma, Charles C. Coddington, Elizabeth A. Stewart

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Cervical ectopic pregnancies (CEPs) are increasingly being managed conservatively. However, the efficacy of specific conservative approaches such as the single-dose intramuscular (IM) methotrexate (MTX) therapy has not been evaluated. We report the successful management of 2 consecutive CEPs in the same patient with single-dose IM MTX therapy, and review published cases of CEPs treated with a similar regimen, to determine the efficacy of this approach. CASE: In our case, both CEPs resolved with single-dose IM MTX, and the patient subsequently had a successful term delivery. A Medline/OVID English language search, covering the period 1982–2012, identified 38 additional cases of CEPs treated with single-dose IM MTX. Of the total 40 cases analyzed, including our 2 cases, 30 (75%) were successfully treated, with complete remission. Of the 27 cases with no embryonic cardiac activity, 25 (93%) were successfully treated with single-dose IM MTX. Conclusion: Appropriately selected cases of CEPs can be successfully managed with single-dose IM MTX with very low complication rates and preservation of future fertility potential.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalJournal of Reproductive Medicine
Volume60
Issue number1
StatePublished - Feb 1 2015

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Ectopic Pregnancy
Methotrexate
Therapeutics
Fertility Preservation
Language

Keywords

  • Cervical pregnancy
  • Ectopic pregnancy
  • Embryo transfer
  • Methotrexate
  • Recurrent ectopic pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Single-dose intramuscular methotrexate treatment of cervical ectopic pregnancy : A case report. / Asante, Albert; Verma, Usha; Coddington, Charles C.; Stewart, Elizabeth A.

In: Journal of Reproductive Medicine, Vol. 60, No. 1, 01.02.2015, p. 78-82.

Research output: Contribution to journalArticle

Asante, Albert ; Verma, Usha ; Coddington, Charles C. ; Stewart, Elizabeth A. / Single-dose intramuscular methotrexate treatment of cervical ectopic pregnancy : A case report. In: Journal of Reproductive Medicine. 2015 ; Vol. 60, No. 1. pp. 78-82.
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