Single-cell analysis of olfactory neurogenesis and differentiation in adult humans

Michael A. Durante, Stefan Kurtenbach, Zoukaa B. Sargi, J. William Harbour, Rhea Choi, Sarah Kurtenbach, Garrett M. Goss, Hiroaki Matsunami, Bradley J. Goldstein

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA sequencing analyzing 28,726 cells, we identified neural stem cell and neural progenitor cell pools and neurons. Additionally, we detailed the expression of 140 olfactory receptors. These data from the olfactory neuroepithelium niche provide evidence that neuron production may continue for decades in humans.

Original languageEnglish (US)
Pages (from-to)323-326
Number of pages4
JournalNature Neuroscience
Volume23
Issue number3
DOIs
StatePublished - Mar 1 2020

ASJC Scopus subject areas

  • Neuroscience(all)

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