Single and sequential combination intravesical chemotherapy of murine bladder cancer

Mark S. Soloway, Israel Nissenkorn, Lee W. McCallum, William M. Murphy

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We investigated the effectiveness of intravesically administered drugs on the tumor incidence and tumor size in a FANFT-induced animal model for bladder cancer. In the first experiment 106 C3H/He mice were divided into a control and three treatment groups. Therapy consisted of either cis-diamminedichloroplatinum (II) (DDP), mitomycin C, or thio-tepa. There was a reduction in the tumor incidence in all treated groups; this was statistically significant for those receiving mitomycin C (p < 0.04) and DDP (p < 0.001). No significant difference in the mean or median tumor weight (an index of tumor volume) between the treated and control groups was found. In a second experiment intravesical combination chemotherapy was compared to single-agent therapy. Animals received either doxorubicin hydrochloride (Adriamycin), mitomycin C, thio-tepa, mitomycin C + doxorubicin, or mitomycin C + thio-tepa. Although there was no significant difference in tumor incidence among the groups with the exception of mice receiving thio-tepa, animals receiving sequential combination chemotherapy had lower mean and median bladder weights suggesting an improved therapeutic effect.

Original languageEnglish (US)
Pages (from-to)169-175
Number of pages7
JournalUrology
Volume19
Issue number2
DOIs
StatePublished - Feb 1982

ASJC Scopus subject areas

  • Urology

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