Abstract
Unintended intraoperative awareness occurs in one to two individuals out of every one thousand treated with general anesthesia. Patients that experience intraoperative awareness have significant post-operative psychological sequelae. The ability to detect intraoperative awareness is currently suboptimal because the mechanism employed by anesthetic drugs to impair consciousness remains poorly understood. Studies have suggested that evoked potentials (EP) may be used to monitor the depth of anesthesia. Both transient and steady state responses can be simultaneously extracted using the Continuous Loop Averaging Deconvolution (CLAD) method with specially designed CLAD sequences. 20 Hz and 30 Hz jittered CLAD sequences in addition to 5 Hz isochronic and 40 Hz jittered CLAD sequences were applied in baseline awake and general anesthesia conditions. A qualitative method to assess the extracted EPs was developed in this study, termed Randomized Split Set Average (RSSA). The results showed that EPs extracted during general anesthesia require a greater number of sweeps to obtain a signal-to-noise ratio comparable to that observed in EPs extracted during the awake state. Therefore, the development of a real time or quasi real time EP monitoring system for anesthesia provides an increased challenge. The RSSA employed in this study is a useful method for assessing the signal quality of EP responses.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
| Pages | 3472-3475 |
| Number of pages | 4 |
| DOIs | |
| State | Published - Dec 14 2012 |
| Event | 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States Duration: Aug 28 2012 → Sep 1 2012 |
Other
| Other | 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 |
|---|---|
| Country | United States |
| City | San Diego, CA |
| Period | 8/28/12 → 9/1/12 |
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ASJC Scopus subject areas
- Computer Vision and Pattern Recognition
- Signal Processing
- Biomedical Engineering
- Health Informatics
Cite this
Simultaneously extracted transient and steady-state evoked responses during general anesthesia : Variability of different rates. / Castro-Llanos, Alexander; Bohorquez, Jorge; McNeer, Richard; Ozdamar, Ozcan.
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2012. p. 3472-3475 6346713.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Simultaneously extracted transient and steady-state evoked responses during general anesthesia
T2 - Variability of different rates
AU - Castro-Llanos, Alexander
AU - Bohorquez, Jorge
AU - McNeer, Richard
AU - Ozdamar, Ozcan
PY - 2012/12/14
Y1 - 2012/12/14
N2 - Unintended intraoperative awareness occurs in one to two individuals out of every one thousand treated with general anesthesia. Patients that experience intraoperative awareness have significant post-operative psychological sequelae. The ability to detect intraoperative awareness is currently suboptimal because the mechanism employed by anesthetic drugs to impair consciousness remains poorly understood. Studies have suggested that evoked potentials (EP) may be used to monitor the depth of anesthesia. Both transient and steady state responses can be simultaneously extracted using the Continuous Loop Averaging Deconvolution (CLAD) method with specially designed CLAD sequences. 20 Hz and 30 Hz jittered CLAD sequences in addition to 5 Hz isochronic and 40 Hz jittered CLAD sequences were applied in baseline awake and general anesthesia conditions. A qualitative method to assess the extracted EPs was developed in this study, termed Randomized Split Set Average (RSSA). The results showed that EPs extracted during general anesthesia require a greater number of sweeps to obtain a signal-to-noise ratio comparable to that observed in EPs extracted during the awake state. Therefore, the development of a real time or quasi real time EP monitoring system for anesthesia provides an increased challenge. The RSSA employed in this study is a useful method for assessing the signal quality of EP responses.
AB - Unintended intraoperative awareness occurs in one to two individuals out of every one thousand treated with general anesthesia. Patients that experience intraoperative awareness have significant post-operative psychological sequelae. The ability to detect intraoperative awareness is currently suboptimal because the mechanism employed by anesthetic drugs to impair consciousness remains poorly understood. Studies have suggested that evoked potentials (EP) may be used to monitor the depth of anesthesia. Both transient and steady state responses can be simultaneously extracted using the Continuous Loop Averaging Deconvolution (CLAD) method with specially designed CLAD sequences. 20 Hz and 30 Hz jittered CLAD sequences in addition to 5 Hz isochronic and 40 Hz jittered CLAD sequences were applied in baseline awake and general anesthesia conditions. A qualitative method to assess the extracted EPs was developed in this study, termed Randomized Split Set Average (RSSA). The results showed that EPs extracted during general anesthesia require a greater number of sweeps to obtain a signal-to-noise ratio comparable to that observed in EPs extracted during the awake state. Therefore, the development of a real time or quasi real time EP monitoring system for anesthesia provides an increased challenge. The RSSA employed in this study is a useful method for assessing the signal quality of EP responses.
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U2 - 10.1109/EMBC.2012.6346713
DO - 10.1109/EMBC.2012.6346713
M3 - Conference contribution
SN - 9781424441198
SP - 3472
EP - 3475
BT - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ER -