TY - GEN
T1 - Simultaneous identification of causal genes and dys-regulated pathways in complex diseases
AU - Kim, Yoo Ah
AU - Wuchty, Stefan
AU - Przytycka, Teresa M.
PY - 2010/12/23
Y1 - 2010/12/23
N2 - In complex diseases different genotypic perturbations of the cellular system often lead to the same phenotype. While characteristic genomic alterations in many cancers exist, other combinations of genomic perturbations potentially lead to the same disease, dysregulating important pathways of the cellular system. In this study, we developed novel computational methods to identify dysregulated pathways and their direct causes in individual patients or patient groups. Specifically, we introduced efficient and powerful graph theoretic algorithms to identify such dysregulated pathways and their causal genes and applied our methods to a large set of glioma specific molecular data.
AB - In complex diseases different genotypic perturbations of the cellular system often lead to the same phenotype. While characteristic genomic alterations in many cancers exist, other combinations of genomic perturbations potentially lead to the same disease, dysregulating important pathways of the cellular system. In this study, we developed novel computational methods to identify dysregulated pathways and their direct causes in individual patients or patient groups. Specifically, we introduced efficient and powerful graph theoretic algorithms to identify such dysregulated pathways and their causal genes and applied our methods to a large set of glioma specific molecular data.
KW - Biological pathway
KW - Complex disease
KW - Copy number variation
KW - Genetic variations
KW - Glioma
KW - Graph theoretic algorithm
UR - http://www.scopus.com/inward/record.url?scp=78650267786&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650267786&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-12683-3_17
DO - 10.1007/978-3-642-12683-3_17
M3 - Conference contribution
AN - SCOPUS:78650267786
SN - 3642126820
SN - 9783642126826
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 263
EP - 280
BT - Research in Computational Molecular Biology - 14th Annual International Conference, RECOMB 2010, Proceedings
T2 - 14th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2010
Y2 - 25 April 2010 through 28 April 2010
ER -