Simultaneous identification of causal genes and dys-regulated pathways in complex diseases

Yoo Ah Kim; Stefan Wuchty; Teresa M. Przytycka

doi:10.1007/978-3-642-12683-3_17

Simultaneous identification of causal genes and dys-regulated pathways in complex diseases

Yoo Ah Kim, Stefan Wuchty, Teresa M. Przytycka

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Scopus citations

Abstract

In complex diseases different genotypic perturbations of the cellular system often lead to the same phenotype. While characteristic genomic alterations in many cancers exist, other combinations of genomic perturbations potentially lead to the same disease, dysregulating important pathways of the cellular system. In this study, we developed novel computational methods to identify dysregulated pathways and their direct causes in individual patients or patient groups. Specifically, we introduced efficient and powerful graph theoretic algorithms to identify such dysregulated pathways and their causal genes and applied our methods to a large set of glioma specific molecular data.

Original language	English (US)
Title of host publication	Research in Computational Molecular Biology - 14th Annual International Conference, RECOMB 2010, Proceedings
Pages	263-280
Number of pages	18
DOIs	https://doi.org/10.1007/978-3-642-12683-3_17
State	Published - Dec 23 2010
Externally published	Yes
Event	14th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2010 - Lisbon, Portugal Duration: Apr 25 2010 → Apr 28 2010

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	6044 LNBI
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Other

Other	14th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2010
Country	Portugal
City	Lisbon
Period	4/25/10 → 4/28/10

Keywords

Biological pathway
Complex disease
Copy number variation
Genetic variations
Glioma
Graph theoretic algorithm

ASJC Scopus subject areas

Theoretical Computer Science
Computer Science(all)

Access to Document

10.1007/978-3-642-12683-3_17

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Cite this

Kim, Y. A., Wuchty, S., & Przytycka, T. M. (2010). Simultaneous identification of causal genes and dys-regulated pathways in complex diseases. In Research in Computational Molecular Biology - 14th Annual International Conference, RECOMB 2010, Proceedings (pp. 263-280). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6044 LNBI). https://doi.org/10.1007/978-3-642-12683-3_17

Simultaneous identification of causal genes and dys-regulated pathways in complex diseases. / Kim, Yoo Ah; Wuchty, Stefan; Przytycka, Teresa M.

Research in Computational Molecular Biology - 14th Annual International Conference, RECOMB 2010, Proceedings. 2010. p. 263-280 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6044 LNBI).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kim, YA, Wuchty, S & Przytycka, TM 2010, Simultaneous identification of causal genes and dys-regulated pathways in complex diseases. in Research in Computational Molecular Biology - 14th Annual International Conference, RECOMB 2010, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 6044 LNBI, pp. 263-280, 14th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2010, Lisbon, Portugal, 4/25/10. https://doi.org/10.1007/978-3-642-12683-3_17

Kim YA, Wuchty S, Przytycka TM. Simultaneous identification of causal genes and dys-regulated pathways in complex diseases. In Research in Computational Molecular Biology - 14th Annual International Conference, RECOMB 2010, Proceedings. 2010. p. 263-280. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-642-12683-3_17

Kim, Yoo Ah ; Wuchty, Stefan ; Przytycka, Teresa M. / Simultaneous identification of causal genes and dys-regulated pathways in complex diseases. Research in Computational Molecular Biology - 14th Annual International Conference, RECOMB 2010, Proceedings. 2010. pp. 263-280 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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