Simultaneous foveal and parafoveal electroretinograms in hereditary degeneration of the central retina

Bruno Bagolini, Vittorio Porciatti, Benedetto Falsini, Massimo Neroni, Antonello Fadda, Erasmo Merendino, Giuseppe Moretti

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Simultaneous foveal and parafoveal electroretinograms (ERG) in response to two identical checks (6 degrees per side) alternating at constant mean luminance were recorded in 26 patients (52 eyes) affected by central hereditary chorioretinal diseases and in 14 age-matched normal subjects (14 eyes). Patients were divided into four groups according to clinical diagnoses: 1. Stargardt's disease; 2. cone dystrophy; 3. vitelliform degeneration; 4. pattern dystrophy. The amplitude and latency of the foveal ERG and the amplitude ratio between foveal and parafoveal ERG (F:PF ratio) were measured. The mean foveal ERG amplitude was significantly lower than the control mean in all patient groups. The foveal ERG latency showed a trend to a increase in all pathological groups. However, this difference was not statistically significant. The mean value of F:PF ratio was significantly reduced as compared with the control mean in Stargardt's disease and cone dystrophy only. In 46 of 52 affected eyes (88.5%) at least one of the electrophysiological parameters was abnormal. Our results suggest that the simultaneous foveal and parafoveal ERG recording may be a sensitive technique in hereditary degenerations of the central retina. This method may also contribute to a better understanding of cone degeneration pathophysiology.

Original languageEnglish
Pages (from-to)435-443
Number of pages9
JournalDocumenta Ophthalmologica
Volume71
Issue number4
DOIs
StatePublished - Apr 1 1989
Externally publishedYes

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Retina
Inborn Genetic Diseases
Stargardt disease 1

Keywords

  • foveal electroretinogram
  • hereditary macular diseases

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Simultaneous foveal and parafoveal electroretinograms in hereditary degeneration of the central retina. / Bagolini, Bruno; Porciatti, Vittorio; Falsini, Benedetto; Neroni, Massimo; Fadda, Antonello; Merendino, Erasmo; Moretti, Giuseppe.

In: Documenta Ophthalmologica, Vol. 71, No. 4, 01.04.1989, p. 435-443.

Research output: Contribution to journalArticle

Bagolini, Bruno ; Porciatti, Vittorio ; Falsini, Benedetto ; Neroni, Massimo ; Fadda, Antonello ; Merendino, Erasmo ; Moretti, Giuseppe. / Simultaneous foveal and parafoveal electroretinograms in hereditary degeneration of the central retina. In: Documenta Ophthalmologica. 1989 ; Vol. 71, No. 4. pp. 435-443.
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