TY - JOUR
T1 - Simultaneous expression of CD2 on a B‐cell, small lymphocytic neoplasm
AU - Viciana, Ana L.
AU - Lancet, Frederick C.
AU - Chamizo, Wilfredo
AU - Voigt, Walter
AU - Ruiz, Phillip
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1994/3/15
Y1 - 1994/3/15
N2 - An unusual neoplasm, best classified as a B-cell chronic lymphocytic leukemia on the basis of cytofluorographic, immunohistologic, and gene rearrangement analysis also co-expressed the T-cell associated marker CD2 (sheep erythrocyte receptor), but without other cell markers restricted to T cells. This case was associated with a more aggressive course than typically seen with B-CLL or malignant lymphoma, small lymphocytic type, implying along with previous reports that CD2 expression may serve as a marker of small lymphocytic tumor cell behavior and the ultimate clinical course. Thus, surface phenotypic analysis of these particular hematopoietic neoplasms may serve not only for identification of the malignancy, but could also render prognostic information.
AB - An unusual neoplasm, best classified as a B-cell chronic lymphocytic leukemia on the basis of cytofluorographic, immunohistologic, and gene rearrangement analysis also co-expressed the T-cell associated marker CD2 (sheep erythrocyte receptor), but without other cell markers restricted to T cells. This case was associated with a more aggressive course than typically seen with B-CLL or malignant lymphoma, small lymphocytic type, implying along with previous reports that CD2 expression may serve as a marker of small lymphocytic tumor cell behavior and the ultimate clinical course. Thus, surface phenotypic analysis of these particular hematopoietic neoplasms may serve not only for identification of the malignancy, but could also render prognostic information.
KW - B-CLL
KW - immunoperoxidase
KW - immunophenotype
KW - sheep erythrocyte receptor
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U2 - 10.1002/cyto.990180109
DO - 10.1002/cyto.990180109
M3 - Article
C2 - 7915983
AN - SCOPUS:0027959326
VL - 18
SP - 42
EP - 48
JO - Cytometry Part B - Clinical Cytometry
JF - Cytometry Part B - Clinical Cytometry
SN - 1552-4949
IS - 1
ER -