Simultaneous and Interleaved Multinuclear Chemical-Shift Imaging, a Method for Concurrent, Localized Spectroscopy

Oded Gonen, Joseph Murphy-Boesch, Ravi Srinivasan, Jiani Hu, Hong Jiang, Radka Stoyanova, Truman R. Brown

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A method is proposed for carrying out chemical-shift imaging simultaneously on several nuclei (1H and 31P in this example), using a commercial clinical NMR imager fitted with a second RF channel and a dual-tuned birdcage coil to fit the human head. Nuclei of different γ are examined at the same field of view by exciting each nucleus successively at times proportional to γ during the same phase-encoding gradient waveform. Thus, each higher-γ nucleus is exposed to a smaller area of the gradient. Additionally, since in vivo protons typically have a shorter T1 and roughly an order of magnitude higher sensitivity than phosphorus, it is possible to interleave 1H-only acquisitions between the simultaneous 1H, 31P observations while the lower-γ nucleus relaxes. Consequently, additional information is obtained with either higher spatial resolution or greater sensitivity (more signal averaging) without lengthening the duration of the examination.

Original languageEnglish (US)
Pages (from-to)26-33
Number of pages8
JournalJournal of Magnetic Resonance, Series B
Volume104
Issue number1
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Engineering(all)

Fingerprint Dive into the research topics of 'Simultaneous and Interleaved Multinuclear Chemical-Shift Imaging, a Method for Concurrent, Localized Spectroscopy'. Together they form a unique fingerprint.

  • Cite this