Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort

Mika Naganawa, Jean Dominique Gallezot, Sjoerd J. Finnema, David Matuskey, Adam Mecca, Nabeel B. Nabulsi, David Labaree, Jim Ropchan, Robert T. Malison, Deepak Cyril D'Souza, Irina Esterlis, Kamil Detyniecki, Christopher H. van Dyck, Yiyun Huang, Richard E. Carson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

11C-UCB-J ((R)-1-((3-(11C-methyl-11C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) is a PET tracer for synaptic vesicle glycoprotein 2A, which may be a marker of synaptic density. To simplify the scan protocol, SUV ratios (SUVRs) were compared with model-based nondisplaceable binding potential (BPND) to select the optimal time window in healthy and neuropsychiatric subjects. Methods: In total, 141 scans were acquired for 90 min. Arterial blood sampling and metabolite analysis were conducted. SUVR-1 (centrum semiovale reference region) was computed for six 30-min windows and compared with 1-tissue-compartment model BPND Simulations were performed to assess the time dependency of SUVR-1. Results: Greater correlation and less bias were observed for SUVR-1 at later time windows for all subjects. Simulations showed that the agreement between SUVR-1 and BPND is time-dependent. Conclusion: The 60- to 90-min period provided the best match between SUVR-1 and BPND (-1% ± 7%); thus, a short scan is sufficient for accurate quantification of 11C-UCB-J-specific binding.

Original languageEnglish (US)
Pages (from-to)418-421
Number of pages4
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume62
Issue number3
DOIs
StatePublished - Mar 1 2021
Externally publishedYes

Keywords

  • brain imaging
  • PET
  • SUVR
  • SV2A
  • synaptic vesicle protein 2A

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'Simplified Quantification of <sup>11</sup>C-UCB-J PET Evaluated in a Large Human Cohort'. Together they form a unique fingerprint.

Cite this