Simplified PET measurement for evaluating histamine H 1 receptors in human brains using [ 11C]doxepin

Hideki Mochizuki; Yuichi Kimura; Kenji Ishii; Keiichi Oda; Toru Sasaki; Manabu Tashiro; Kazuhiko Yanai; Kiichi Ishiwata

doi:10.1016/j.nucmedbio.2004.06.009

Simplified PET measurement for evaluating histamine H ₁ receptors in human brains using [ ¹¹C]doxepin

Hideki Mochizuki, Yuichi Kimura, Kenji Ishii, Keiichi Oda, Toru Sasaki, Manabu Tashiro, Kazuhiko Yanai, Kiichi Ishiwata

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The aim of this study was to develop simplified positron emission tomography measurement using [ ¹¹C]doxepin ([ ¹¹C]DOX) to evaluate histamine H ₁ receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [ ¹¹C]DOX, estimated quantitatively with a two-compartment model, and the [ ¹¹C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [ ¹¹C]DOX-H1R binding.

Original language	English (US)
Pages (from-to)	1005-1011
Number of pages	7
Journal	Nuclear Medicine and Biology
Volume	31
Issue number	8
DOIs	https://doi.org/10.1016/j.nucmedbio.2004.06.009
State	Published - Nov 1 2004
Externally published	Yes

Keywords

Histamine H receptor
Static PET scanning
[ C]Doxepin

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

Access to Document

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Simplified PET measurement for evaluating histamine H ₁ receptors in human brains using [ ¹¹C]doxepin. / Mochizuki, Hideki; Kimura, Yuichi; Ishii, Kenji; Oda, Keiichi; Sasaki, Toru; Tashiro, Manabu; Yanai, Kazuhiko; Ishiwata, Kiichi.

In: Nuclear Medicine and Biology, Vol. 31, No. 8, 01.11.2004, p. 1005-1011.

Research output: Contribution to journal › Article › peer-review

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