Simplified PET measurement for evaluating histamine H 1 receptors in human brains using [ 11C]doxepin

Hideki Mochizuki; Yuichi Kimura; Kenji Ishii; Keiichi Oda; Toru Sasaki; Manabu Tashiro; Kazuhiko Yanai; Kiichi Ishiwata

doi:10.1016/j.nucmedbio.2004.06.009

Simplified PET measurement for evaluating histamine H ₁ receptors in human brains using [ ¹¹C]doxepin

Hideki Mochizuki, Yuichi Kimura, Kenji Ishii, Keiichi Oda, Toru Sasaki, Manabu Tashiro, Kazuhiko Yanai, Kiichi Ishiwata

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The aim of this study was to develop simplified positron emission tomography measurement using [ ¹¹C]doxepin ([ ¹¹C]DOX) to evaluate histamine H ₁ receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [ ¹¹C]DOX, estimated quantitatively with a two-compartment model, and the [ ¹¹C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [ ¹¹C]DOX-H1R binding.

Original language	English (US)
Pages (from-to)	1005-1011
Number of pages	7
Journal	Nuclear Medicine and Biology
Volume	31
Issue number	8
DOIs	https://doi.org/10.1016/j.nucmedbio.2004.06.009
State	Published - Nov 1 2004
Externally published	Yes

Keywords

Histamine H receptor
Static PET scanning
[ C]Doxepin

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.nucmedbio.2004.06.009

Cite this

Simplified PET measurement for evaluating histamine H ₁ receptors in human brains using [ ¹¹C]doxepin. / Mochizuki, Hideki; Kimura, Yuichi; Ishii, Kenji; Oda, Keiichi; Sasaki, Toru; Tashiro, Manabu; Yanai, Kazuhiko; Ishiwata, Kiichi.

In: Nuclear Medicine and Biology, Vol. 31, No. 8, 01.11.2004, p. 1005-1011.

Research output: Contribution to journal › Article › peer-review

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AU - Yanai, Kazuhiko

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