Simplified PET measurement for evaluating histamine H 1 receptors in human brains using [ 11C]doxepin

Hideki Mochizuki, Yuichi Kimura, Kenji Ishii, Keiichi Oda, Toru Sasaki, Manabu Tashiro, Kazuhiko Yanai, Kiichi Ishiwata

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The aim of this study was to develop simplified positron emission tomography measurement using [ 11C]doxepin ([ 11C]DOX) to evaluate histamine H 1 receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [ 11C]DOX, estimated quantitatively with a two-compartment model, and the [ 11C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [ 11C]DOX-H1R binding.

Original languageEnglish (US)
Pages (from-to)1005-1011
Number of pages7
JournalNuclear Medicine and Biology
Volume31
Issue number8
DOIs
StatePublished - Nov 1 2004
Externally publishedYes

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Keywords

  • Histamine H receptor
  • Static PET scanning
  • [ C]Doxepin

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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