Abstract
The aim of this study was to develop simplified positron emission tomography measurement using [ 11C]doxepin ([ 11C]DOX) to evaluate histamine H 1 receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [ 11C]DOX, estimated quantitatively with a two-compartment model, and the [ 11C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [ 11C]DOX-H1R binding.
Original language | English (US) |
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Pages (from-to) | 1005-1011 |
Number of pages | 7 |
Journal | Nuclear Medicine and Biology |
Volume | 31 |
Issue number | 8 |
DOIs | |
State | Published - Nov 1 2004 |
Externally published | Yes |
Keywords
- Histamine H receptor
- Static PET scanning
- [ C]Doxepin
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
- Cancer Research