Simple bedside additive tool for prediction of in-hospital mortality after percutaneous coronary interventions

Mauro Moscucci, Eva Kline-Rogers, David Share, Michael O'Donnell, Ann Maxwell-Eward, William L. Meengs, Phillip Kraft, Anthony C. DeFranco, James L. Chambers, Kirit Patel, John G. McGinnity, Kim A. Eagle

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

Background - Risk-adjustment models for percutaneous coronary intervention (PCI) mortality have been recently reported, but application in bedside prediction of prognosis for individual patients remains untested. Methods and Results - Between July 1, 1997 and September 30, 1999, 10 796 consecutive procedures were performed in a consortium of 8 hospitals. Predictors of in-hospital mortality were identified by use of multivariate logistic regression analysis. The final model was validated by use of the bootstrap technique. Additional validation was performed on an independent data set of 5863 consecutive procedures performed between October 1, 1999, and August 30, 2000. An additive risk-prediction score was developed by rounding coefficients of the logistic regression model to the closest half-integer, and a visual bedside tool for the prediction of individual patient prognosis was developed. In this patient population, the in-hospital mortality rate was 1.6%. Multivariate regression analysis identified acute myocardial infarction, cardiogenic shock, history of cardiac arrest, renal insufficiency, low ejection fraction, peripheral vascular disease, lesion characteristics, female sex, and advanced age as independent predictors of death. The model had excellent discrimination (area under the receiver operating characteristic curve, 0.90) and was accurate for prediction of mortality among different subgroups. Near-perfect correlation existed between calculated scores and observed mortality, with higher scores associated with higher mortality. Conclusions - Accurate predictions of individual patient risk of mortality associated with PCI can be achieved with a simple bedside tool. These predictions could be used during discussions of prognosis before and after PCI.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalCirculation
Volume104
Issue number3
StatePublished - Jul 17 2001

Fingerprint

Percutaneous Coronary Intervention
Hospital Mortality
Mortality
Logistic Models
Regression Analysis
Risk Adjustment
Cardiogenic Shock
Peripheral Vascular Diseases
Heart Arrest
ROC Curve
Sex Characteristics
Renal Insufficiency
Multivariate Analysis
Myocardial Infarction
Population

Keywords

  • Angioplasty
  • Coronary disease
  • Risk factors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Moscucci, M., Kline-Rogers, E., Share, D., O'Donnell, M., Maxwell-Eward, A., Meengs, W. L., ... Eagle, K. A. (2001). Simple bedside additive tool for prediction of in-hospital mortality after percutaneous coronary interventions. Circulation, 104(3), 263-268.

Simple bedside additive tool for prediction of in-hospital mortality after percutaneous coronary interventions. / Moscucci, Mauro; Kline-Rogers, Eva; Share, David; O'Donnell, Michael; Maxwell-Eward, Ann; Meengs, William L.; Kraft, Phillip; DeFranco, Anthony C.; Chambers, James L.; Patel, Kirit; McGinnity, John G.; Eagle, Kim A.

In: Circulation, Vol. 104, No. 3, 17.07.2001, p. 263-268.

Research output: Contribution to journalArticle

Moscucci, M, Kline-Rogers, E, Share, D, O'Donnell, M, Maxwell-Eward, A, Meengs, WL, Kraft, P, DeFranco, AC, Chambers, JL, Patel, K, McGinnity, JG & Eagle, KA 2001, 'Simple bedside additive tool for prediction of in-hospital mortality after percutaneous coronary interventions', Circulation, vol. 104, no. 3, pp. 263-268.
Moscucci M, Kline-Rogers E, Share D, O'Donnell M, Maxwell-Eward A, Meengs WL et al. Simple bedside additive tool for prediction of in-hospital mortality after percutaneous coronary interventions. Circulation. 2001 Jul 17;104(3):263-268.
Moscucci, Mauro ; Kline-Rogers, Eva ; Share, David ; O'Donnell, Michael ; Maxwell-Eward, Ann ; Meengs, William L. ; Kraft, Phillip ; DeFranco, Anthony C. ; Chambers, James L. ; Patel, Kirit ; McGinnity, John G. ; Eagle, Kim A. / Simple bedside additive tool for prediction of in-hospital mortality after percutaneous coronary interventions. In: Circulation. 2001 ; Vol. 104, No. 3. pp. 263-268.
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