Abstract
The macaque immunodeficiency syndrome has many parallels to AIDS in humans. Affected monkeys develop profound, prolonged T lymphocyte dysfunction and die of lymphomas or opportunistic infections. We recently isolated a virus that we call SIV from four sick macaque monkeys. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of human AIDS. The pathogenicity of this newly isolated virus was tested in macaque monkeys. Five of six died between 127 and 352 days following inoculation. The animals developed a wasting syndrome and died with adenovirus pancreatitis and/or pneumonia and primary retroviral encephalitis. Immunological abnormalities in these animals included a decrease in circulating T4+ lymphocytes and depressed peripheral blood lymphocyte proliferative response to pokeweed mitogen. The SIV monkey model holds great promise for testing antiviral agents and for the development of vaccines against AIDS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 501-507 |
| Number of pages | 7 |
| Journal | Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc |
| Volume | 1 |
| State | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
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Simian models for AIDS. / Daniel, M. D.; Desrosiers, Ronald Charles; Letvin, N. L.; King, N. W.; Schmidt, D. K.; Sehgal, P.; Hunt, R. D.
In: Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc, Vol. 1, 1987, p. 501-507.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Simian models for AIDS.
AU - Daniel, M. D.
AU - Desrosiers, Ronald Charles
AU - Letvin, N. L.
AU - King, N. W.
AU - Schmidt, D. K.
AU - Sehgal, P.
AU - Hunt, R. D.
PY - 1987
Y1 - 1987
N2 - The macaque immunodeficiency syndrome has many parallels to AIDS in humans. Affected monkeys develop profound, prolonged T lymphocyte dysfunction and die of lymphomas or opportunistic infections. We recently isolated a virus that we call SIV from four sick macaque monkeys. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of human AIDS. The pathogenicity of this newly isolated virus was tested in macaque monkeys. Five of six died between 127 and 352 days following inoculation. The animals developed a wasting syndrome and died with adenovirus pancreatitis and/or pneumonia and primary retroviral encephalitis. Immunological abnormalities in these animals included a decrease in circulating T4+ lymphocytes and depressed peripheral blood lymphocyte proliferative response to pokeweed mitogen. The SIV monkey model holds great promise for testing antiviral agents and for the development of vaccines against AIDS.
AB - The macaque immunodeficiency syndrome has many parallels to AIDS in humans. Affected monkeys develop profound, prolonged T lymphocyte dysfunction and die of lymphomas or opportunistic infections. We recently isolated a virus that we call SIV from four sick macaque monkeys. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of human AIDS. The pathogenicity of this newly isolated virus was tested in macaque monkeys. Five of six died between 127 and 352 days following inoculation. The animals developed a wasting syndrome and died with adenovirus pancreatitis and/or pneumonia and primary retroviral encephalitis. Immunological abnormalities in these animals included a decrease in circulating T4+ lymphocytes and depressed peripheral blood lymphocyte proliferative response to pokeweed mitogen. The SIV monkey model holds great promise for testing antiviral agents and for the development of vaccines against AIDS.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023462484&partnerID=8YFLogxK
M3 - Article
C2 - 3480063
AN - SCOPUS:0023462484
VL - 1
SP - 501
EP - 507
JO - Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc
JF - Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc
SN - 1043-6995
ER -