Simian immunodeficiency virus-specific CD8+ T cells recognize Vpr- and Rev-derived epitopes early after infection

Jonah B. Sacha, Matthew B. Buechler, Laura P. Newman, Jason Reed, Lyle T. Wallace, John T. Loffredo, Nancy A. Wilson, David I. Watkins

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The kinetics of CD8+ T cell epitope presentation contribute to the antiviral efficacy of these cells yet remain poorly defined. Here, we demonstrate presentation of virion-derived Vpr peptide epitopes early after viral penetration and prior to presentation of Vif-derived epitopes, which required de novo Vif synthesis. Two Rev epitopes exhibited differential presentation kinetics, with one Rev epitope presented within 1 h of infection. We also demonstrate that cytolytic activity mirrors the recognition kinetics of infected cells. These studies show for the first time that Vpr- and Rev-specific CD8+ T cells recognize and kill simian immunodeficiency virus (SIV)-infected CD4+ T cells early after SIV infection.

Original languageEnglish (US)
Pages (from-to)10907-10912
Number of pages6
JournalJournal of virology
Volume84
Issue number20
DOIs
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Sacha, J. B., Buechler, M. B., Newman, L. P., Reed, J., Wallace, L. T., Loffredo, J. T., Wilson, N. A., & Watkins, D. I. (2010). Simian immunodeficiency virus-specific CD8+ T cells recognize Vpr- and Rev-derived epitopes early after infection. Journal of virology, 84(20), 10907-10912. https://doi.org/10.1128/JVI.01357-10