Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid

Juan P. Giraldo-Vela, Alex T. Bean, Richard Rudersdorf, Lyle T. Wallace, John T. Loffredo, Priscilla Erickson, Nancy A. Wilson, David Watkins

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We recently demonstrated that vaccinated rhesus macaques controlled viral replication of a heterologous SIV challenge. Here, we analyzed anamnestic SIV-specific CD4+ T-cell responses expanding immediately after challenge and show that successful vaccinees consistently targeted a short region of the Gag-p27 Capsid (amino acids 249-291). We have also defined the major histocompatibility complex class II (MHC-II) restricting alleles for several of these responses and show that DQ-restricted CD4+ T-cells depend on unique combinations of both the DQA and DQB alleles. Analysis of SIV-specific CD4+ T-cell responses elicited by a successful vaccine may have important implications in the understanding of vaccine design.

Original languageEnglish
Pages (from-to)701-707
Number of pages7
JournalImmunogenetics
Volume62
Issue number10
DOIs
StatePublished - Oct 1 2010
Externally publishedYes

Fingerprint

Simian Immunodeficiency Virus
Capsid
T-Lymphocytes
Vaccines
Alleles
Major Histocompatibility Complex
Macaca mulatta
Amino Acids

Keywords

  • CD4+ T-cells
  • HIV
  • Major histocompatibility complex
  • Mamu-MHC
  • Rhesus macaques
  • SIV

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Giraldo-Vela, J. P., Bean, A. T., Rudersdorf, R., Wallace, L. T., Loffredo, J. T., Erickson, P., ... Watkins, D. (2010). Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid. Immunogenetics, 62(10), 701-707. https://doi.org/10.1007/s00251-010-0473-9

Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid. / Giraldo-Vela, Juan P.; Bean, Alex T.; Rudersdorf, Richard; Wallace, Lyle T.; Loffredo, John T.; Erickson, Priscilla; Wilson, Nancy A.; Watkins, David.

In: Immunogenetics, Vol. 62, No. 10, 01.10.2010, p. 701-707.

Research output: Contribution to journalArticle

Giraldo-Vela, JP, Bean, AT, Rudersdorf, R, Wallace, LT, Loffredo, JT, Erickson, P, Wilson, NA & Watkins, D 2010, 'Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid', Immunogenetics, vol. 62, no. 10, pp. 701-707. https://doi.org/10.1007/s00251-010-0473-9
Giraldo-Vela JP, Bean AT, Rudersdorf R, Wallace LT, Loffredo JT, Erickson P et al. Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid. Immunogenetics. 2010 Oct 1;62(10):701-707. https://doi.org/10.1007/s00251-010-0473-9
Giraldo-Vela, Juan P. ; Bean, Alex T. ; Rudersdorf, Richard ; Wallace, Lyle T. ; Loffredo, John T. ; Erickson, Priscilla ; Wilson, Nancy A. ; Watkins, David. / Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid. In: Immunogenetics. 2010 ; Vol. 62, No. 10. pp. 701-707.
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