Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid

Juan P. Giraldo-Vela, Alex T. Bean, Richard Rudersdorf, Lyle T. Wallace, John T. Loffredo, Priscilla Erickson, Nancy A. Wilson, David I. Watkins

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We recently demonstrated that vaccinated rhesus macaques controlled viral replication of a heterologous SIV challenge. Here, we analyzed anamnestic SIV-specific CD4+ T-cell responses expanding immediately after challenge and show that successful vaccinees consistently targeted a short region of the Gag-p27 Capsid (amino acids 249-291). We have also defined the major histocompatibility complex class II (MHC-II) restricting alleles for several of these responses and show that DQ-restricted CD4+ T-cells depend on unique combinations of both the DQA and DQB alleles. Analysis of SIV-specific CD4+ T-cell responses elicited by a successful vaccine may have important implications in the understanding of vaccine design.

Original languageEnglish (US)
Pages (from-to)701-707
Number of pages7
JournalImmunogenetics
Volume62
Issue number10
DOIs
StatePublished - Oct 1 2010
Externally publishedYes

Keywords

  • CD4+ T-cells
  • HIV
  • Major histocompatibility complex
  • Mamu-MHC
  • Rhesus macaques
  • SIV

ASJC Scopus subject areas

  • Immunology
  • Genetics

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  • Cite this

    Giraldo-Vela, J. P., Bean, A. T., Rudersdorf, R., Wallace, L. T., Loffredo, J. T., Erickson, P., Wilson, N. A., & Watkins, D. I. (2010). Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid. Immunogenetics, 62(10), 701-707. https://doi.org/10.1007/s00251-010-0473-9