Simian immunodeficiency virus-induced meningoencephalitis

Natural history and retrospective study

D. J. Ringler, R. D. Hung, Ronald Charles Desrosiers, M. D. Daniel, L. V. Chalifoux, N. W. King

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Simian immunodeficiency virus (SIV) is a lentivirus with morphological and antigenic similarities to human immunodeficiency virus, the causative agent of acquired immunodeficiency syndrome (AIDS) of humans. Macaque monkeys infected with SIV show profound immunological impairment, clinically characterized by multiple opportunistic infections and neoplasms. Retrospective examination of autopsy tissue from 27 SIV-infected animals demonstrated that approximately 60% of the experimentally inoculated animals had a meningoencephalitis characterized by perivascular infiltrates of macrophages and multinucleate giant cells in the white and gray matter and leptomeninges. Ultrastructurally, these macrophages contained typical lentiviral particles within membrane-bound intracytoplasmic vacuoles. Other findings in the central nervous system included discrete randomly located neuroglial nodules, endothelial hypertrophy, and leptomeningeal thickening. The results indicate that the meningoencephalitis induced by SIV in monkeys is similar to the lesions of the central nervous system in patients with AIDS and that SIV infection in the macaque is a useful animal model to study the pathogenesis of human immunodeficiency virus-related subacute encephalitis or AIDS encephalopathy.

Original languageEnglish (US)
JournalAnnals of Neurology
Volume23
Issue numberSUPPL.
StatePublished - 1988
Externally publishedYes

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Simian Immunodeficiency Virus
Meningoencephalitis
Natural History
Retrospective Studies
Acquired Immunodeficiency Syndrome
Macaca
Haplorhini
Central Nervous System
Macrophages
HIV
Lentivirus
Opportunistic Infections
Brain Diseases
Virus Diseases
Encephalitis
Giant Cells
Vacuoles
Hypertrophy
Autopsy
Animal Models

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ringler, D. J., Hung, R. D., Desrosiers, R. C., Daniel, M. D., Chalifoux, L. V., & King, N. W. (1988). Simian immunodeficiency virus-induced meningoencephalitis: Natural history and retrospective study. Annals of Neurology, 23(SUPPL.).

Simian immunodeficiency virus-induced meningoencephalitis : Natural history and retrospective study. / Ringler, D. J.; Hung, R. D.; Desrosiers, Ronald Charles; Daniel, M. D.; Chalifoux, L. V.; King, N. W.

In: Annals of Neurology, Vol. 23, No. SUPPL., 1988.

Research output: Contribution to journalArticle

Ringler, DJ, Hung, RD, Desrosiers, RC, Daniel, MD, Chalifoux, LV & King, NW 1988, 'Simian immunodeficiency virus-induced meningoencephalitis: Natural history and retrospective study', Annals of Neurology, vol. 23, no. SUPPL..
Ringler, D. J. ; Hung, R. D. ; Desrosiers, Ronald Charles ; Daniel, M. D. ; Chalifoux, L. V. ; King, N. W. / Simian immunodeficiency virus-induced meningoencephalitis : Natural history and retrospective study. In: Annals of Neurology. 1988 ; Vol. 23, No. SUPPL.
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