TY - JOUR
T1 - Silver leaf nylon dressing to prevent radiation dermatitis in patients undergoing chemotherapy and external beam radiotherapy to the perineum
AU - Vuong, Té
AU - Franco, Eduardo
AU - Lehnert, Shirley
AU - Lambert, Christine
AU - Portelance, Lorraine
AU - Nasr, Elie
AU - Faria, Sergio
AU - Hay, John
AU - Larsson, Stephan
AU - Shenouda, George
AU - Souhami, Luis
AU - Wong, Frances
AU - Freeman, Carolyn
PY - 2004/7/1
Y1 - 2004/7/1
N2 - Purpose Silver-leaf nylon dressing (SLND) has been shown to have effective antimicrobial activity and to enhance healing in burns and skin grafts. The purpose of this study was to evaluate the value of SLND in preventing radiation dermatitis in patients undergoing radiotherapy to target volumes that included the perineum and concurrent chemotherapy. Methods and materials Fifteen consecutive patients with either anal canal or gynecologic cancer were offered the SLND as a preventive intervention. The evaluation was based on standardized photographs taken at the end of treatment. A historical control group of 15 patients with the same neoplasms who received standard skin care was assessed in the same fashion. Ten observers unaware of the treatment intervention were enrolled in the evaluation of the skin changes. The Mann-Whitney U test was used to assess the statistical significance of the differences in the dermatitis scores between the two patient groups. Results The mean dermatitis score for controls was 2.62 (standard deviation, 0.48). The mean score for the SLND group was significantly lower at 1.16 (standard deviation, 0.40; p <0.0001). Conclusion The results of this study suggest that SLND is effective in reducing radiation dermatitis, apparently because of its antibacterial properties.
AB - Purpose Silver-leaf nylon dressing (SLND) has been shown to have effective antimicrobial activity and to enhance healing in burns and skin grafts. The purpose of this study was to evaluate the value of SLND in preventing radiation dermatitis in patients undergoing radiotherapy to target volumes that included the perineum and concurrent chemotherapy. Methods and materials Fifteen consecutive patients with either anal canal or gynecologic cancer were offered the SLND as a preventive intervention. The evaluation was based on standardized photographs taken at the end of treatment. A historical control group of 15 patients with the same neoplasms who received standard skin care was assessed in the same fashion. Ten observers unaware of the treatment intervention were enrolled in the evaluation of the skin changes. The Mann-Whitney U test was used to assess the statistical significance of the differences in the dermatitis scores between the two patient groups. Results The mean dermatitis score for controls was 2.62 (standard deviation, 0.48). The mean score for the SLND group was significantly lower at 1.16 (standard deviation, 0.40; p <0.0001). Conclusion The results of this study suggest that SLND is effective in reducing radiation dermatitis, apparently because of its antibacterial properties.
KW - Prevention
KW - Radiation-induced dermatitis
KW - Silver leaf nylon dressing
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U2 - 10.1016/j.ijrobp.2003.11.031
DO - 10.1016/j.ijrobp.2003.11.031
M3 - Article
C2 - 15183484
AN - SCOPUS:2942588574
VL - 59
SP - 809
EP - 814
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
SN - 0360-3016
IS - 3
ER -