Silicone oil in repair of retinal detachments caused by necrotizing retinitis in HIV infection

Janet L Davis, M. S. Serfass, M. Y. Lai, D. K. Trask, S. P. Azen

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Objective: To evaluate the safety and efficacy of 1000- and 5000- centistoke silicone oil as retinal tamponades for the treatment of retinal detachments secondary to necrotizing retinitis in patients with human immunodeficiency virus (HIV) infection. Design: A prospective observational study. Setting: Community and university-based ophthalmology clinics. Patients: Three hundred fifty patients with HIV infection, who had 407 eyes with retinal detachments secondary to necrotizing retinitis. Intervention: Vitrectomy surgery for retinal detachment with 1000- or 5000-centistoke silicone oil as the retinal tamponade. Outcome Measures: Efficacy was measured both by anatomic success (defined as complete retinal attachment or macular attachment) and by visual acuity success (defined as preservation of visual acuity or ambulatory vision). Safety was determined by the rate of complications, including abnormal intraocular pressure and corneal and lens opacification. Results: At the last follow-up examination, the retina was completely attached in 287 (73%) of 393 eyes, the macula was attached in 370 eyes (94%), 268 eyes (68%) had ambulatory vision, and visual acuity was preserved in 219 (56%) of 388 eyes. Corneal opacification, hypotony, and silicone oil emulsification were present in 4%, 2%, and 1% of eyes, respectively. One eye had elevated intraocular pressure. Of the 57 patients who had both eyes treated, 35 died, of whom four (11%) had non-ambulatory vision in both eyes. Of the 293 patients who had one eye treated, 122 died, of whom 44 (36%) died with nonambulatory vision in the treated eye. The median time to cataract was 192 days; to nonambulatory vision, 474 days; and to death, 204 days. Conclusions: Silicone oil repair of retinal detachments in necrotizing retinitis is an efficacious and safe procedure that delays or prevents loss of vision in advanced HIV disease.

Original languageEnglish
Pages (from-to)1401-1409
Number of pages9
JournalArchives of Ophthalmology
Volume113
Issue number11
StatePublished - Jan 1 1995

Fingerprint

Silicone Oils
Retinitis
Retinal Detachment
Virus Diseases
HIV
Visual Acuity
Intraocular Pressure
Safety
Intraocular Lenses
Vitrectomy
Ophthalmology
Cataract
Observational Studies
Retina

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Davis, J. L., Serfass, M. S., Lai, M. Y., Trask, D. K., & Azen, S. P. (1995). Silicone oil in repair of retinal detachments caused by necrotizing retinitis in HIV infection. Archives of Ophthalmology, 113(11), 1401-1409.

Silicone oil in repair of retinal detachments caused by necrotizing retinitis in HIV infection. / Davis, Janet L; Serfass, M. S.; Lai, M. Y.; Trask, D. K.; Azen, S. P.

In: Archives of Ophthalmology, Vol. 113, No. 11, 01.01.1995, p. 1401-1409.

Research output: Contribution to journalArticle

Davis, JL, Serfass, MS, Lai, MY, Trask, DK & Azen, SP 1995, 'Silicone oil in repair of retinal detachments caused by necrotizing retinitis in HIV infection', Archives of Ophthalmology, vol. 113, no. 11, pp. 1401-1409.
Davis, Janet L ; Serfass, M. S. ; Lai, M. Y. ; Trask, D. K. ; Azen, S. P. / Silicone oil in repair of retinal detachments caused by necrotizing retinitis in HIV infection. In: Archives of Ophthalmology. 1995 ; Vol. 113, No. 11. pp. 1401-1409.
@article{ad926b73d6af4c52b34a7e21d93f4ffb,
title = "Silicone oil in repair of retinal detachments caused by necrotizing retinitis in HIV infection",
abstract = "Objective: To evaluate the safety and efficacy of 1000- and 5000- centistoke silicone oil as retinal tamponades for the treatment of retinal detachments secondary to necrotizing retinitis in patients with human immunodeficiency virus (HIV) infection. Design: A prospective observational study. Setting: Community and university-based ophthalmology clinics. Patients: Three hundred fifty patients with HIV infection, who had 407 eyes with retinal detachments secondary to necrotizing retinitis. Intervention: Vitrectomy surgery for retinal detachment with 1000- or 5000-centistoke silicone oil as the retinal tamponade. Outcome Measures: Efficacy was measured both by anatomic success (defined as complete retinal attachment or macular attachment) and by visual acuity success (defined as preservation of visual acuity or ambulatory vision). Safety was determined by the rate of complications, including abnormal intraocular pressure and corneal and lens opacification. Results: At the last follow-up examination, the retina was completely attached in 287 (73{\%}) of 393 eyes, the macula was attached in 370 eyes (94{\%}), 268 eyes (68{\%}) had ambulatory vision, and visual acuity was preserved in 219 (56{\%}) of 388 eyes. Corneal opacification, hypotony, and silicone oil emulsification were present in 4{\%}, 2{\%}, and 1{\%} of eyes, respectively. One eye had elevated intraocular pressure. Of the 57 patients who had both eyes treated, 35 died, of whom four (11{\%}) had non-ambulatory vision in both eyes. Of the 293 patients who had one eye treated, 122 died, of whom 44 (36{\%}) died with nonambulatory vision in the treated eye. The median time to cataract was 192 days; to nonambulatory vision, 474 days; and to death, 204 days. Conclusions: Silicone oil repair of retinal detachments in necrotizing retinitis is an efficacious and safe procedure that delays or prevents loss of vision in advanced HIV disease.",
author = "Davis, {Janet L} and Serfass, {M. S.} and Lai, {M. Y.} and Trask, {D. K.} and Azen, {S. P.}",
year = "1995",
month = "1",
day = "1",
language = "English",
volume = "113",
pages = "1401--1409",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "11",

}

TY - JOUR

T1 - Silicone oil in repair of retinal detachments caused by necrotizing retinitis in HIV infection

AU - Davis, Janet L

AU - Serfass, M. S.

AU - Lai, M. Y.

AU - Trask, D. K.

AU - Azen, S. P.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Objective: To evaluate the safety and efficacy of 1000- and 5000- centistoke silicone oil as retinal tamponades for the treatment of retinal detachments secondary to necrotizing retinitis in patients with human immunodeficiency virus (HIV) infection. Design: A prospective observational study. Setting: Community and university-based ophthalmology clinics. Patients: Three hundred fifty patients with HIV infection, who had 407 eyes with retinal detachments secondary to necrotizing retinitis. Intervention: Vitrectomy surgery for retinal detachment with 1000- or 5000-centistoke silicone oil as the retinal tamponade. Outcome Measures: Efficacy was measured both by anatomic success (defined as complete retinal attachment or macular attachment) and by visual acuity success (defined as preservation of visual acuity or ambulatory vision). Safety was determined by the rate of complications, including abnormal intraocular pressure and corneal and lens opacification. Results: At the last follow-up examination, the retina was completely attached in 287 (73%) of 393 eyes, the macula was attached in 370 eyes (94%), 268 eyes (68%) had ambulatory vision, and visual acuity was preserved in 219 (56%) of 388 eyes. Corneal opacification, hypotony, and silicone oil emulsification were present in 4%, 2%, and 1% of eyes, respectively. One eye had elevated intraocular pressure. Of the 57 patients who had both eyes treated, 35 died, of whom four (11%) had non-ambulatory vision in both eyes. Of the 293 patients who had one eye treated, 122 died, of whom 44 (36%) died with nonambulatory vision in the treated eye. The median time to cataract was 192 days; to nonambulatory vision, 474 days; and to death, 204 days. Conclusions: Silicone oil repair of retinal detachments in necrotizing retinitis is an efficacious and safe procedure that delays or prevents loss of vision in advanced HIV disease.

AB - Objective: To evaluate the safety and efficacy of 1000- and 5000- centistoke silicone oil as retinal tamponades for the treatment of retinal detachments secondary to necrotizing retinitis in patients with human immunodeficiency virus (HIV) infection. Design: A prospective observational study. Setting: Community and university-based ophthalmology clinics. Patients: Three hundred fifty patients with HIV infection, who had 407 eyes with retinal detachments secondary to necrotizing retinitis. Intervention: Vitrectomy surgery for retinal detachment with 1000- or 5000-centistoke silicone oil as the retinal tamponade. Outcome Measures: Efficacy was measured both by anatomic success (defined as complete retinal attachment or macular attachment) and by visual acuity success (defined as preservation of visual acuity or ambulatory vision). Safety was determined by the rate of complications, including abnormal intraocular pressure and corneal and lens opacification. Results: At the last follow-up examination, the retina was completely attached in 287 (73%) of 393 eyes, the macula was attached in 370 eyes (94%), 268 eyes (68%) had ambulatory vision, and visual acuity was preserved in 219 (56%) of 388 eyes. Corneal opacification, hypotony, and silicone oil emulsification were present in 4%, 2%, and 1% of eyes, respectively. One eye had elevated intraocular pressure. Of the 57 patients who had both eyes treated, 35 died, of whom four (11%) had non-ambulatory vision in both eyes. Of the 293 patients who had one eye treated, 122 died, of whom 44 (36%) died with nonambulatory vision in the treated eye. The median time to cataract was 192 days; to nonambulatory vision, 474 days; and to death, 204 days. Conclusions: Silicone oil repair of retinal detachments in necrotizing retinitis is an efficacious and safe procedure that delays or prevents loss of vision in advanced HIV disease.

UR - http://www.scopus.com/inward/record.url?scp=0028875712&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028875712&partnerID=8YFLogxK

M3 - Article

C2 - 7487601

AN - SCOPUS:0028875712

VL - 113

SP - 1401

EP - 1409

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 11

ER -