Silent Brain Infarction and Risk of Future Stroke: A Systematic Review and Meta-Analysis

Ajay Gupta, Ashley E. Giambrone, Gino Gialdini, Caitlin Finn, Diana Delgado, Jose Gutierrez, Clinton B Wright, Alexa S. Beiser, Sudha Seshadri, Ankur Pandya, Hooman Kamel

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background and Purpose-Silent brain infarction (SBI) on magnetic resonance imaging has been proposed as a subclinical risk marker for future symptomatic stroke. We performed a systematic review and meta-analysis to summarize the association between magnetic resonance imaging-defined SBI and future stroke risk. Methods-We searched the medical literature to identify cohort studies involving adults with SBI detected by magnetic resonance imaging who were subsequently followed up for incident clinically defined stroke. Study data and quality assessment were recorded in duplicate with disagreements in data extraction resolved by a third reader. Strength association between magnetic resonance imaging-detected SBI and future symptomatic stroke was measured by an hazard ratio. Results-The meta-analysis included 13 studies (14 764 subjects) with a mean follow-up ranging from 25.7 to 174 months. SBI predicted the occurrence of stroke with a random effects crude relative risk of 2.94 (95% confidence interval, 2.24-3.86, P

Original languageEnglish (US)
Pages (from-to)719-725
Number of pages7
JournalStroke
Volume47
Issue number3
DOIs
StatePublished - Mar 1 2016

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Brain Infarction
Meta-Analysis
Stroke
Magnetic Resonance Imaging
Cohort Studies
Confidence Intervals

Keywords

  • brain infarction
  • infarction
  • magnetic resonance imaging
  • risk factors
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Gupta, A., Giambrone, A. E., Gialdini, G., Finn, C., Delgado, D., Gutierrez, J., ... Kamel, H. (2016). Silent Brain Infarction and Risk of Future Stroke: A Systematic Review and Meta-Analysis. Stroke, 47(3), 719-725. https://doi.org/10.1161/STROKEAHA.115.011889

Silent Brain Infarction and Risk of Future Stroke : A Systematic Review and Meta-Analysis. / Gupta, Ajay; Giambrone, Ashley E.; Gialdini, Gino; Finn, Caitlin; Delgado, Diana; Gutierrez, Jose; Wright, Clinton B; Beiser, Alexa S.; Seshadri, Sudha; Pandya, Ankur; Kamel, Hooman.

In: Stroke, Vol. 47, No. 3, 01.03.2016, p. 719-725.

Research output: Contribution to journalArticle

Gupta, A, Giambrone, AE, Gialdini, G, Finn, C, Delgado, D, Gutierrez, J, Wright, CB, Beiser, AS, Seshadri, S, Pandya, A & Kamel, H 2016, 'Silent Brain Infarction and Risk of Future Stroke: A Systematic Review and Meta-Analysis', Stroke, vol. 47, no. 3, pp. 719-725. https://doi.org/10.1161/STROKEAHA.115.011889
Gupta A, Giambrone AE, Gialdini G, Finn C, Delgado D, Gutierrez J et al. Silent Brain Infarction and Risk of Future Stroke: A Systematic Review and Meta-Analysis. Stroke. 2016 Mar 1;47(3):719-725. https://doi.org/10.1161/STROKEAHA.115.011889
Gupta, Ajay ; Giambrone, Ashley E. ; Gialdini, Gino ; Finn, Caitlin ; Delgado, Diana ; Gutierrez, Jose ; Wright, Clinton B ; Beiser, Alexa S. ; Seshadri, Sudha ; Pandya, Ankur ; Kamel, Hooman. / Silent Brain Infarction and Risk of Future Stroke : A Systematic Review and Meta-Analysis. In: Stroke. 2016 ; Vol. 47, No. 3. pp. 719-725.
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